Results 61 to 70 of about 2,063,842 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Clinical and Microbiological Effects of Streptococcus salivarius K12 Lozenges and Zinc Mouthrinse on Persistent Intra-Oral Halitosis

Microorganisms
Background and Objectives: Halitosis is a common condition with substantial psychosocial impact, frequently driven by intra-oral biofilm, tongue coating, and reduced salivary clearance.
Adrian Bolos, Otilia Cornelia Bolos, Edida Maghet, Alexandra Ioana Danila, Raluca Briceag, Bogdan Andrei Bumbu   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Prediction of Drug-Likeness Using Deep Autoencoder Neural Networks

Frontiers in Genetics, 2018
Due to diverse reasons, most drug candidates cannot eventually become marketed drugs. Developing reliable computational methods for prediction of drug-likeness of candidate compounds is of vital importance to improve the success rate of drug discovery ...
Qiwan Hu, Mudong Feng, Luhua Lai, Luhua Lai, Jianfeng Pei   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Response of Egyptian Hybrid Rice One Cultivar to Zinc Sulphate, Potassium Sulphate and Magnesium Silicate as Foliar Application. [PDF]

Journal of Plant Production, 2017
The two field experiments were conducted during 2015 and 2016 seasons at the Experimental Farm of Rice Research Department (RRD), Sakha, Kafrelsheikh, Egypt.
Mariam Wissa
doaj   +1 more source

Zinc‐containing compounds for personal care applications [PDF]

International Journal of Cosmetic Science, 2018
AbstractIt is well‐known that zinc ions are widely used in cosmetic products. Their popularity is associated with the multifunctional profile of Zn2+, which is classified as an essential chemical element in the human body. This review examines numerous beneficial biological properties of zinc‐containing compounds and classifies the compounds used in ...
M. Abendrot, U. Kalinowska‐Lis
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Synergistic Effect of some Halide Ions on the Inhibition of Zinc Corrosion in Hydrocchloric Acid by Tetrahydro carbazole Derivatives Compounds.

International Journal of Electrochemical Science, 2013
The synergistic effects of some ions such as KI,KCl and KBr on the corrosion inhibition of zinc in 0.4 M HCl by tetrahydrocarbazole derivatives compounds has been investigated using weight loss measurements.
M. Abdallah, S.T. Atwa, M.M. Salem, A.S. Fouda   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source