Results 121 to 130 of about 19,002 (159)
374 A phase IB trial of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors
Howard Streicher +9 more
doaj +1 more source
Intraperitoneal ziv-aflibercept effectively manages refractory ascites in colorectal cancer patients. [PDF]
Lu CS +11 more
europepmc +1 more source
Preclinical Investigations of Intravitreal Ziv-Aflibercept
BACKGROUND AND OBJECTIVE: To investigate the retinal safety of intravitreal (IVT) ziv-aflibercept in rabbits. MATERIALS AND METHODS: Eighteen rabbits were given an IVT injection of ziv-aflibercept (25 mg/mL) or aflibercept (40 mg/mL) and examined by funduscopy, electroretinography ...
Michel Eid Farah +2 more
exaly +4 more sources
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Intravitreal Ziv-Aflibercept: A Comprehensive Review
Seminars in Ophthalmology, 2019Background: Age-related macular degeneration is the leading cause of blindness in adults over the age of 50 in the United States of America. Neovascular age-related macular degeneration (nAMD) is sight-threatening, but can be treated by three currently utilized, intravitreally administered drugs: aflibercept, bevacizumab, and ranibizumab.
Daniel Barmas-Alamdari +2 more
exaly +3 more sources
Analytical comparability assessment on glycosylation of ziv-aflibercept and the biosimilar candidate
International Journal of Biological Macromolecules, 2021Ziv-aflibercept (aflibercept) is a recombinant fusion protein which combines the portions of human vascular endothelial growth factor receptors extracellular domains fused to the Fc portion of human IgG1. It is a highly sialylated glycoprotein with 5 N-glycosylation sites.
Qing Li, Huarong Xu, Yanhong Wang
exaly +3 more sources
Long-term safety and efficacy of ziv-aflibercept in retinal diseases [PDF]
To investigate the long-term safety of intravitreal ziv-aflibercept in eyes receiving six or more intravitreal injections of ziv-aflibercept, an off-label substitute to the approved aflibercept.Consecutive patients with retinal disease receiving six or more of intravitreal 0.05 mL ziv-aflibercept (1.25 mg) injections were followed monthly in three ...
Ahmad M Mansour +5 more
openaire +3 more sources
INTRAVITREAL INJECTIONS OF ZIV-AFLIBERCEPT FOR DIABETIC MACULAR EDEMA
Diabetic macular edema is the leading cause of blindness in young adults in developed countries. Beyond metabolic control, several therapies have been studied such as laser treatment and intravitreal injections of corticosteroids or anti-vascular endothelial growth factor drugs.
Gabriel Costa de, Andrade +5 more
openaire +3 more sources

