Results 41 to 50 of about 4,747 (177)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Tuning the photonic band gap in cholesteric liquid crystals by temperature-dependent dopant solubility [PDF]

, 2006
We have investigated the physical and optical properties of the left-handed chiral dopant ZLI-811 mixed in a nematic liquid crystal (LC) host BL006.
Doyle, Charlie, Wu, Shin-Tson, Huang, Yuhua, Zhou, Ying   +3 more
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Przypowieść o kąkolu w pszenicy (Mt 13,24-30.36-43) w duszpasterskiej interpretacji św. Augustyna

Śląskie Studia Historyczno-Teologiczne, 2015
Problem „świętości” Kościoła należy do tych wątków teologicznych, które pomimo upływu wieków zachowują swoją aktualność. Dla św. Augustyna w podjęciu tego problemu niezwykle cenną była przypowieść o kąkolu w pszenicy (Mt 13,24-30.36-43).
Wojciech Kamczyk
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Is expressed in the dorsal diencephalon and is able to suppress ZLI formation

, 2011
Copyright information:Taken from "Tissue interactions in the developing chick diencephalon"http://www.neuraldevelopment.com/content/2/1/25Neural Development 2007;2():25-25.Published online 13 Nov 2007PMCID:PMC2217525. Stage HH15 chick head, hybridisation
Maria Flavia Guinazu (39513), David Chambers (16065), Clemens Kiecker (39515), Andrew Lumsden (39514)   +3 more
core   +1 more source

Tajna dyplomacja – procesy pokazowe – wojna medialna. Polska i Litwa oraz zakon krzyżacki w okresie soboru w Konstancji (1414–1418)

Biuletyn Polskiej Misji Historycznej, 2013
W czasie soboru w Konstancji konflikt między państwem Zakonu Krzyżackiego w Prusach a Rzeczypospolitą przerodził się w działania tajnej dyplomacji, procesy pokazowe oraz wojnę medialną.
Andreas Rüther
doaj   +1 more source

Dynamics of Size and Shape Variation During Embryonic Development in the Balkan Crested Newt

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Morphological variance in Triturus ivanbureschi embryos fluctuates during the tailbud phase, coinciding with developmental arrest caused by the balanced lethal system. Prehatching embryos show uniform variance. Our study reveals dynamics of morphological variability during early development and provides a baseline for further studies.
Marko Bugarčić, Ana Ivanović, Milena Cvijanović, Maja Ajduković, Marija Drobnjaković, Ben Wielstra, Tijana Vučić   +6 more
wiley   +1 more source