Results 51 to 60 of about 4,747 (177)

Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon [PDF]

, 2006
Midway between the anterior neural border and the midbrain-hindbrain boundary, two well-known local signalling centres in the early developing brain, is a further transverse boundary with putative signalling properties - the zona limitans intrathalamica (
Wolf, O, Brand, M, Steffen Scholpp, Brand, Michael, Lumsden, A, Scholpp, Steffen, Michael Brand, Lumsden, Andrew, Brand, M., Wolf, O., Lumsden, A., Andrew Lumsden, Scholpp, S, Olivia Wolf, Wolf, Olivia, Scholpp, S.   +15 more
core   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

The Effect of teaching by Computerized Educational Program and Cooperative Learning in Seventh Grade Student's achievement of science in Aqaba Governorate [PDF]

, 2007
استهدفت الدراسة بيان أثر كل من التدريس باستخدام برنامج تعليمي محوسب والتعلم التعاوني في تحصيل طلبة الصف السابع الأساسي في مادة العلوم بمحافظة العقبة، تكونت عينة الدراسة من (57) طالبا و (58‏) طالبة، تم اختيارها بطريقة قصديه من طلبة الصف السابع الأساسي في ...
البشايرة، زيد علي, منزلاوي، عمر كرم   +1 more
core   +2 more sources

Wolność w Liście do Galatów na tle myśli greckiej

Collectanea Theologica
Wolność dla starożytnych Greków miała trzy aspekty: osobisty jako przeciwieństwo niewoli, polityczny w mieście-państwie (niepoddanym żadnemu imperium) oraz wewnętrzny mędrca, niezależny od sytuacji zewnętrznej.
Michał Wojciechowski
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, Volume 13, Issue 49, 3 September 2026.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

The Secretome Derived From Human Umbilical Cord Mesenchymal Stem Cells Improves Skin Photoaging by Enhancing Mitophagy to Inhibit the cGAS‐STING Pathway

Aging Cell, Volume 25, Issue 9, September 2026.
HUC‐MSC‐derived SCT alleviates UV‐induced skin photoaging. It acts by enhancing mitophagy to clear damaged mitochondria, thereby suppressing the pro‐inflammatory cGAS‐STING pathway. This work identifies SCT as a novel cell‐free therapy targeting mitochondrial quality control to counteract sterile inflammation in aging. ABSTRACT Ultraviolet (UV)‐induced
Tingting Tang, Meifen Lin, Jingjing Yang, Xinyu Yang, Xunhong Xu, Xuan Wang, Yarui Zhang, Qimei Chen, Shan Zhao, Chenhui Guo, Hao Zhang, Min Zhang, Lin Zhang, Xueer Wang   +13 more
wiley   +1 more source

Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate

, 2013
The structural complexity of the brain depends on precise molecular and cellular regulatory mechanisms orchestrated by regional morphogenetic organizers.
Navarro-Garberi, Maria, Bueno, Carlos Roberto, Martínez-Ferre, Almudena, Martínez, Salvador   +3 more
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, Volume 13, Issue 43, 3 August 2026.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Co-culture of prechordal and epichordal neural explants results in ZLI induction

, 2011
Copyright information:Taken from "Tissue interactions in the developing chick diencephalon"http://www.neuraldevelopment.com/content/2/1/25Neural Development 2007;2():25-25.Published online 13 Nov 2007PMCID:PMC2217525.
Maria Flavia Guinazu (39513), David Chambers (16065), Clemens Kiecker (39515), Andrew Lumsden (39514)   +3 more
core   +1 more source