Results 251 to 260 of about 27,376,677 (317)

ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells

open access: yesJournal of Cerebral Blood Flow and Metabolism, 2017
Hu Zhang   +8 more
semanticscholar   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

open access: yesSmall, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul   +8 more
wiley   +1 more source

Inulin‐Butyrate Nanogel for Modulation of Gut Microbiome, Intestinal Barrier, and Regulatory T‐Cells in Colitis

open access: yesSmall, EarlyView.
IBD is driven by a vicious cycle of dysbiosis, barrier dysfunction, and immune dysregulation. We developed an inulin–butyrate conjugate nanogel (IBN) that accumulates in inflamed colon and releases butyrate via microbial inulinase/esterase. The inulin shell remodels the microbiome, while localized butyrate strengthens barrier integrity and promotes ...
Nayoon Park   +7 more
wiley   +1 more source

Unraveling Water Sorption in Single‐Crystal MOFs: Insights from Spectroscopy and Modeling on the Role of Structure, Composition, and Guest Molecules

open access: yesSmall, EarlyView.
Water scarcity drives the search for efficient atmospheric water harvesting (AWH) materials. This study explores the impact of metal substitution (Zr to Hf) and linker exchange (fumaric to trimesic acid) on the water sorption performance of MOF‐801 and MOF‐808.
Jonas Tittel   +7 more
wiley   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

open access: yesSmall Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto   +12 more
wiley   +1 more source

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