Results 91 to 100 of about 29,714,140 (226)

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Diurnal testosterone oscillations gate drug delivery via phase separation of ZO-1 at the blood-testis barrier in mice

Communications Biology
The blood-testis barrier is essential for sperm development but also blocks the delivery of non-hormonal male contraceptives and other germ-cell-targeting therapies.
Zhaoyang Wang, Qihong Wu, Xun Tang, Lu Li, Jingxian Deng, Rufei Huang, Wanqing Lin, Yadong Huang, Yan Yang   +8 more
doaj   +1 more source

Inhibition of MicroRNA‐155 Supports Endothelial Tight Junction Integrity Following Oxygen‐Glucose Deprivation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Brain microvascular endothelial cells form a highly selective blood brain barrier regulated by the endothelial tight junctions. Cerebral ischemia selectively targets tight junction protein complexes, which leads to significant damage to ...
Juan Carlos Pena‐Philippides, Amy Sabrina Gardiner, Ernesto Caballero‐Garrido, Rong Pan, Yiliang Zhu, Tamara Roitbak   +5 more
doaj   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Short‐Term 6PPD‐Q Exposure alters Tight‐Junction‐Related Gene Expression Without Acute Lethality in Japanese Medaka Oryzias latipes

Journal of Applied Toxicology, EarlyView.
ABSTRACT 6PPD‐quinone (6PPD‐Q), a transformation product of the tire antioxidant 6PPD, causes acute mortality in several salmonid species, but its toxicity varies markedly among fish species. Disruption of vascular‐barrier integrity and inflammatory signaling has been proposed as a key mechanism of 6PPD‐Q toxicity.
Kyoshiro Hiki
wiley   +1 more source

Zonula Occludens-1 and E-cadherin Are Coordinately Expressed in the Mouse Uterus with the Initiation of Implantation and Decidualization

Developmental Biology, 1999
Two-way interactions between the blastocyst trophectoderm and the uterine luminal epithelium are essential for implantation. The key events of this process are cell-cell contact of trophectoderm cells with uterine luminal epithelial cells, controlled invasion of trophoblast cells through the luminal epithelium and the basement membrane, transformation ...
Paria, Bibhash C., Zhao, Xuemei, Das, Sanjoy K., Dey, Sudhansu K., Yoshinaga, Koji   +4 more
openaire   +2 more sources

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Zonula Occludens-1 Is a Scaffolding Protein for Signaling Molecules [PDF]

Journal of Biological Chemistry, 2002
Tobias N. Meyer, Catherine Schwesinger, Bradley M. Denker   +2 more
openaire   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source