Results 151 to 160 of about 29,405 (257)

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. [PDF]

, 2018
BackgroundObesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available ...
Chang, C-J, Ko, Y-F, Lai, H-C, Lin, C-S, Lu, C-C, Lu, J-J, Martel, J, Ojcius, DM, Tsai, Y-H, Wu, T-R, Yeh, T-S, Young, JD   +11 more
core  

Atractylodes Macrocephala Polysaccharides Ameliorate Diabetic Hepatorenal Injury and Remodel Gut Microbiota in Mice

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Atractylodes macrocephala polysaccharides alleviate diabetic liver and kidney injury in HFD/STZ‐induced mice by improving gut microbiota composition, restoring intestinal barrier function, and partially correcting disturbed unsaturated fatty acid metabolism.
Jiali Wu, Xuenan Liu, Yangpeng Li, Jing Liu, Biao Jia, Hongye Peng, Qin Yuan, Wen Liu, Shengpeng Wang, Duosheng Luo, Xianglu Rong, Wenliang Lv, Jiao Guo   +12 more
wiley   +1 more source

Crocin Supplementation Mitigates DSS‐Induced Ulcerative Colitis by Promoting Autophagy and Modulating Gut Microbiota in Mice

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Crocin enhanced intestinal barrier integrity and alleviated colonic inflammation in DSS‐induced UC mice. Crocin promoted autophagy by targeting the AMPK/mTOR pathway. Crocin reshaped gut microbiota composition of UC mice. ABSTRACT Crocin has been widely recognized for its anti‐inflammatory and antioxidant properties.
Jiaoyang Xu, Xiaoyu Han, Zizheng Nie, Qinglong Cao, Mu Zhang, Yingying Liu, Chenyang Wu, Jun Yang, Shufen Han   +8 more
wiley   +1 more source

Therapeutic Galectin‐3 Apheresis Improves Sepsis Outcomes Through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study

MedComm, Volume 7, Issue 4, April 2026.
Gal‐3 apheresis reduces neutrophil hyperactivation (CXCL2/CXCL8, MPO, NETs), preserves endothelial barrier function (tight junctions, vWF/VCAM‐1/ICAM‐1), and attenuates PI3K/AKT/HIF‐1α signaling. These coordinated effects significantly improve hemodynamics, reduce pulmonary edema (ELWI), lower vasopressor and fluid requirements, and increase survival ...
Zhongyi Sun, Jiachen Qu, Sheng Peng, Yanan Hu, Amity Eliaz, Glenn M. Chertow, Isaac Eliaz, Zhiyong Peng   +7 more
wiley   +1 more source

Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging [PDF]

, 2018
Chen, Wei, Gao, Fabao, Song, Li, Tao, Chuanyuan, Wang, Chunhua, Wang, Yu, Xu, Ziqian, Zhang, Ruzhi, Zheng, Jie   +8 more
core   +2 more sources

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

Charakterisierung der Struktur, Funktion und Wechselwirkungen der Tight Junction Proteine Occludin und Zonula Occludens 1

, 2009
Die tight junction schränken die Diffusion durch den parazellulären Raum in Epithel- und Endothelzellschichten für viele Moleküle stark ein. Dadurch behindern sie die Aufnahme von wasserlöslichen Medikamenten in das dahinterliegende Gewebe. Zwei Proteine, die am tight junction Aufbau mitwirken, sind Zonula Occludens Protein 1 (ZO-1) und Occludin.
openaire   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, Volume 111, Issue 4, Page 1733-1745, 1 April 2026.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source