Results 101 to 110 of about 28,285 (214)
A novel NHERF1 mutation in human breast cancer and effects on malignant progression [PDF]
, 2017 Na+/H+ exchanger regulatory factor 1 (NHERF1) has been reported to interact with post-synaptic density protein/Drosophila disc large tumour suppressor/zonula occludens 1 protein (PDZ) binding proteins by its two PDZ domains.
Cheng, S. +7 more
core +2 more sources
Small, EarlyView.This work explores the tailored functionalization of mesoporous silica nanoparticles (MSN) to improve the oral delivery of insulin, as a case study. Insulin confinement within silica mesopores increased drug solubility, and co‐formulation with succinylated β‐lactoglobulin yielded pH‐responsive tablets that limited gastric release and proteolysis, while
Claudia Iriarte‐Mesa +14 more
wiley +1 more source
Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]
, 2009 The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane +14 more
core
Small Methods, EarlyView.This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto +12 more
wiley +1 more source
NFS JournalThis study investigated the protective effects of immature Citrus nippokoreana fruit extract (CFE) against tumor necrosis factor (TNF)-α/interferon (IFN)-γ-induced barrier disruption in human intestinal epithelial cells.
Ulfah Dwi Kurniawati +5 more
doaj +1 more source
A promising protein responsible for overactive bladder in ovariectomized mice
Taiwanese Journal of Obstetrics & Gynecology, 2017 Objective: Ovariectomy (OVX) in mice is a model mimicking a neuro-electronic proof of an overactive bladder in postmenopausal women. Overactive bladder (OAB) was recently found to be due to an altered gap junction protein in a rat model. Thus, this study
Huey-Yi Chen +4 more
doaj +1 more source
Looking at tricellulin expression in the brain [PDF]
, 2010 Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010It was recently reported the existence of a protein, called tricellulin (TRIC), concentrated at tricellular tight junctions (TJ) but also ...
Mariano, Cibelle Neiva Cavalcanti, 1984-
core
Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier
VIEW, EarlyView.Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan +3 more
wiley +1 more source
Mechanism of enhanced oral absorption of hydrophilic drug incorporated in hydrophobic nanoparticles
International Journal of Nanomedicine, 2013 Liang-Zhong Lv,1 Chen-Qi Tong,1 Jia Yu,1 Min Han,2 Jian-Qing Gao21Department of Pharmacy, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China; 2Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang ...
Lv LZ, Tong CQ, Yu J, Han M, Gao JQ
doaj
British Journal of Pharmacology, EarlyView.Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud +9 more
wiley +1 more source