Results 111 to 120 of about 21,302 (208)

Proteomic screening identifies the zonula occludens protein ZO-1 as a new partner for ADAM12 in invadopodia-like structures

, 2018
International audienceThe epithelial mesenchymal transition (EMT) is a key process for cancer cell invasion and migration. This complex program whereby epithelial tumor cells loose polarity and acquire mesenchymal phenotype is driven by the regulation of
Michael Ruff, Legagneux, Vincent, Dekky, Bassil, Dominique Bonnier, Nathalie Théret, Vincent Legagneux, Theret, Nathalie, Ruff, Michaël, Bonnier, Dominique, Bassil Dekky   +9 more
core   +1 more source

Protein Corona‐Coated Crystal Silica From Sandstorms Amplifies Allergic Rhinitis by Regulating Epithelial Integrity in Mice and Human Nasal Epithelia

Allergy, EarlyView.
Cuishuang Dong, Xu Zhang, Haoyue Wang, Jiajing Cui, Shuai Han, Yibo Wang, Huanying Zhao, Yang Song, Yuan Zhang, Xiaobo Li   +9 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Robotic microinjection enables large-scale transgenic studies of Caenorhabditis elegans

Nature Communications
The nematode Caenorhabditis elegans is widely employed as a model organism to study basic biological mechanisms. However, transgenic C. elegans are generated by manual injection, which remains low-throughput and labor-intensive, limiting the scope of ...
Peng Pan, Michael Zoberman, Pengsong Zhang, Sharanja Premachandran, Sanjana Bhatnagar, Pallavi P. Pilaka-Akella, William Sun, Chengyin Li, Charlotte Martin, Pengfei Xu, Zefang Zhang, Ryan Li, Wesley Hung, Hua Tang, Kailynn MacGillivray, Bin Yu, Runze Zuo, Karinna Pe, Zhen Qin, Shaojia Wang, Ang Li, W. Brent Derry, Mei Zhen, Arneet L. Saltzman, John A. Calarco, Xinyu Liu   +25 more
doaj   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, Volume 101, Issue 8, Page 1980-1996, August 2026.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Structure-­‐function analysis of the C-­‐terminal domain, ZU5, of the Zonula Occludens-­‐1 protein

, 2011
Zonula occludens--‐1 (ZO--‐1) is a large scaffold protein necessary for tight junction formation and signaling. Despite extensive studies of the ZO--‐1 protein, there remains ambiguity concerning the function of the C--‐terminal ZU5 domain.
Brady, Rachel C
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The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Vancomycin Protects Against Lung Injury and Promotes Butyrate Metabolism

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Transplanting the fecal microbiota of patients with lung injury into mice causes an increase in LPS in the mice's blood, thereby leading to chronic lung injury in the mice. Meanwhile, oral administration of vancomycin can enhance colonic butyrate metabolism and improve lung injury in mice.
Jianuo Chen, Shanshan Su, Xi Zhang, Fen Xiong, Hong Zheng, Wenli Zhang, Yuying Shen, Pengcheng Lin, Hongchang Gao, Yuping Li   +9 more
wiley   +1 more source

Zonula occludens-1의 변화를 통한 interleukin-13의 족세포 투과도 증가

, 2013
Dept. of Medicine/박사Purpose: The aim of this study was to investigate whether pathologic changes in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experimental minimal-change nephrotic syndrome (MCNS) model and to determine ...
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