Results 131 to 140 of about 28,285 (214)

Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging [PDF]

, 2018
Chen, Wei, Gao, Fabao, Song, Li, Tao, Chuanyuan, Wang, Chunhua, Wang, Yu, Xu, Ziqian, Zhang, Ruzhi, Zheng, Jie   +8 more
core   +2 more sources

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Sarcodon aspratus Polysaccharide Ameliorates Type 2 Diabetes Mellitus Symptoms by Regulating Intestinal Barrier and Intestinal Microbiota

Foods
Sarcodon aspratus fruiting polysaccharides (SAFP) exhibit multiple therapeutic properties. In this study, a type 2 diabetes mellitus (T2DM) mouse model was established using a high-fat diet (HFD) and streptozotocin to evaluate the antidiabetic potential ...
Dongjing Zhang, Xiuying Sun, Haichao Wang, Lei Chen   +3 more
doaj   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, Volume 111, Issue 4, Page 1733-1745, 1 April 2026.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

Characterizing airway epithelial cultures grown on permeable inserts with different pore densities

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract In vitro airway epithelial models, such as air‐liquid interface (ALI) cultures, are widely used for disease modeling, therapeutic and toxicology testing, and studying epithelial‐environmental interactions. However, it remains unknown whether the pore density of the permeable membrane inserts, on which primary human bronchial epithelial cells ...
T. J. F. Guo, G. K. Singhera, J. Memar Vaghri, W. Y. Liang, J. M. Leung, D. R. Dorscheid   +5 more
wiley   +1 more source

ALOX15‐Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq–PLC–PKC Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ALOX15 expression and its downstream oxylipins, including 12‐HETE and 13‐HODE, are induced in intestinal epithelial and lamina propria immune cells during the early and middle phases of experimental colitis. These endogenous lipid mediators suppress lipopolysaccharide‐induced TNF‐α and IL‐6 production in macrophages without affecting cell viability ...
Adrian Hilman, Yoshiki Ishii, Bambang Dwi Wijatniko, Dina Mustika Rini, Takuya Suzuki   +4 more
wiley   +1 more source

HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2

Scientific Reports
The SARS-CoV-2 E protein through its C-terminal PDZ-binding motif (PBM) interacts with several host PDZ-containing proteins, including Zonula occludens-1 (ZO-1) protein via its PDZ2 domain, thereby contributing to viral pathogenesis.
Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, Ahmed Haouz, Blandine Séon-Méniel, Rodolphe Alves de Sousa, Stéphane Bourg, Didier Desmaële, Bruno Figadère, Nicolas Wolff, Hélène Munier-Lehmann, Célia Caillet-Saguy   +13 more
doaj   +1 more source

Oxytocin supports the barrier integrity of brain endothelial cells via oxytocin receptors. [PDF]

J Neuroendocrinol
Paolini C, Piacentini F, Amato S, Busnelli M, Chini B.   +4 more
europepmc   +1 more source