Results 101 to 110 of about 29,714,162 (232)

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy

Journal of Parkinson’s Disease, 2017
Background: Recent evidence suggests that Parkinson’s disease (PD) is associated with intestinal microbiota dysbiosis, abnormal intestinal permeability, and intestinal inflammation.
Phillip A. Engen, Hemraj B. Dodiya, Ankur Naqib, Christopher B. Forsyth, Stefan J. Green, Robin M. Voigt, Jeffrey H. Kordower, Ece A. Mutlu, Kathleen M. Shannon, Ali Keshavarzian   +9 more
doaj   +1 more source

A proper protocol for isolation of retinal pigment epithelium from rabbit eyes

Advanced Biomedical Research, 2014
Background: Retinal pigment epithelium (RPE) is a hexagonal monolayer of pigmented cells located between the neural retina and the choroid with an essential role for visual function.
Noushin Amirpour, Fereshteh Karamali, Shahnaz Razavi, Ebrahim Esfandiari, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source

Zonula Occludens-1 Is a Scaffolding Protein for Signaling Molecules [PDF]

Journal of Biological Chemistry, 2002
Tobias N. Meyer, Catherine Schwesinger, Bradley M. Denker   +2 more
openaire   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Role of Zonula Occludens (ZO) proteins in regulating kidney collecting duct principal cell proliferation and adhesion

, 2014
The role of tight junctions (TJs) in regulating epithelial cell proliferation in conjuction with scaffolding zonula occludens (ZO) proteins has come to light recently.
Qiao, Xiaomu
core   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Dosage composition for nasal delivery comprising vibrio cholera zonula occludens toxin as absorption enhancer

, 2000
A nasal dosage composition for nasal delivery comprising (A) a therapeutic agent; and (B) zonula occludens toxin, as well as a method for the use of the ...
Uzzau, Sergio, Fasano, Alessio, De Magistris, Maria Teresa, Rappuoli, Rino   +3 more
core  

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source