Results 31 to 40 of about 132,079 (287)

Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection

Angewandte Chemie, EarlyView.
In this research, we show the concept of molecular cages as probes in indicator displacement assays, focusing on scopolamine detection, a drug often used in drug‐facilitated sexual assaults. Drug sensing occurs via the drug‐induced transformation of non‐emissive [Fluorescein2⊂Cage] complex into [Scopolamine⊂Catenane] and highly emissive free ...
Giovanni Montà‐González, Eva Garrido, Estela Climent, Cristian Vicent, Ramón Martínez‐Máñez, Vicente Martí‐Centelles   +5 more
wiley   +2 more sources

An index of fatal toxicity for new psychoactive substances [PDF]

, 2018
The final, definitive version of this paper has been published in Journal of Psychopharmacology, February 2018, published by SAGE Publishing, All rights reserved.An index of fatal toxicity for new psychoactive substances has been developed based solely ...
Corkery, John, King, L.A.
core   +2 more sources

Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self‐Report Questionnaire

Neuropsychopharmacology Reports, 2021
Aims Benzodiazepine receptor agonists (BZ‐RAs) are frequently prescribed to treat insomnia; however, their long‐term use is not recommended. To introduce an appropriate pharmaco‐therapy, the current state and background factors of BZ‐RAs' dependence must
Mai Yamamoto, Ken Inada, Minori Enomoto, Mitsunari Habukawa, Takahisa Hirose, Yuichi Inoue, Jun Ishigooka, Yuichi Kamei, Tsuyoshi Kitajima, Masayuki Miyamoto, Hideto Shinno, Katsuji Nishimura, Motohiro Ozone, Masahiro Takeshima, Mayumi Suzuki, Hidehisa Yamashita, Kazuo Mishima   +16 more
doaj   +1 more source

Treatment strategy for insomnia disorder: Japanese expert consensus

Frontiers in Psychiatry, 2023
PurposeThere is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently ...
Yoshikazu Takaesu, Yoshikazu Takaesu, Hitoshi Sakurai, Yumi Aoki, Yumi Aoki, Masahiro Takeshima, Kenya Ie, Kenya Ie, Kentaro Matsui, Kentaro Matsui, Tomohiro Utsumi, Tomohiro Utsumi, Akiyoshi Shimura, Isa Okajima, Nozomu Kotorii, Nozomu Kotorii, Hidehisa Yamashita, Masahiro Suzuki, Kenichi Kuriyama, Kenichi Kuriyama, Eiji Shimizu, Eiji Shimizu, Kazuo Mishima, Koichiro Watanabe, Ken Inada   +24 more
doaj   +1 more source

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]

, 2017
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa, Kaufman, Daniel L, Middleton, Blake, Tian, Jide   +3 more
core   +1 more source

Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil

Frontiers in Psychiatry, 2022
IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous ...
Rebecca Casari, Antonio Metastasio, Lorenzo Zamboni, Lorenzo Zamboni, Martino Biasioli, Simone Campagnari, Fabio Lugoboni   +6 more
doaj   +1 more source

Effects of insecticidal ketones present in mint plants on GABA A receptor from mammalian neurons [PDF]

, 2017
The genus Mentha, an important member of the Lamiaceae family, is represented by many species commonly known as mint. The insecticidal activity of Mentha oil and its main components has been tested and established against various insects/pests.
Delgado Marín, Leticia Ester, Garcia, Daniel Asmed, Sánchez, Mariela Eugenia   +2 more
core   +2 more sources

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source