Results 41 to 50 of about 1,026 (107)

Coupling between global gray matter BOLD activity and CSF movement is associated with Aβ and tau burden in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Reduced glymphatic clearance may contribute to Alzheimer's disease. Low‐frequency CSF flow, which mediates glymphatic clearance, has tight temporal coupling (i.e., anti‐correlation) to global gray matter activity in resting‐state BOLD‐fMRI. But this coupling strength may decrease with AD.
Gawon Cho, Ryan S O'Dell, Xiao Liu, Helene Benveniste, Daniel Kay, Christopher H van Dyck, Brienne Miner, Adam P Mecca   +7 more
wiley   +1 more source

Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study. [PDF]

Brain, 2022
Holland N, Malpetti M, Rittman T, Mak EE, Passamonti L, Kaalund SS, Hezemans FH, Jones PS, Savulich G, Hong YT, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB.   +13 more
europepmc   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

ePosters Virtual

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Principal component analysis of synaptic density measured with [¹¹C]UCB-J PET in early Alzheimer's disease. [PDF]

Neuroimage Clin, 2023
O'Dell RS, Higgins-Chen A, Gupta D, Chen MK, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi NB, Huang Y, Arnsten AFT, Carson RE, van Dyck CH, Mecca AP.   +16 more
europepmc   +1 more source

Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [¹¹ C]UCB-J Positron Emission Tomography Study. [PDF]

Mov Disord, 2023
Holland N, Jones PS, Savulich G, Naessens M, Malpetti M, Whiteside DJ, Street D, Swann P, Hong YT, Fryer TD, Rittman T, Mulroy E, Aigbirhio FI, Bhatia KP, O'Brien JT, Rowe JB.   +15 more
europepmc   +1 more source

Evaluating infusion methods and simplified quantification of synaptic density in vivo with [¹¹C]UCB-J and [¹⁸F]SynVesT-1 PET. [PDF]

J Cereb Blood Flow Metab, 2023
Asch RH, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson RE.   +5 more
europepmc   +1 more source

Quantitative imaging of mitochondrial and synaptic function in the human brain with 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J

, 2020
The ‘Molecular Imaging of Neurodegenerative Disease: Mitochondria, Associated Proteins & Synapses’ (MIND-MAPS) Consortium was formed to investigate three potential molecular markers of the mitochondrial/endoplasmic reticulum/synaptic axis dysfunction associated with neurodegeneration using positron emission tomography (PET) in the healthy human ...
openaire   +2 more sources

Synaptic Loss in Frontotemporal Dementia Revealed by [¹¹ C]UCB-J Positron Emission Tomography. [PDF]

Ann Neurol, 2023
Malpetti M, Jones PS, Cope TE, Holland N, Naessens M, Rouse MA, Rittman T, Savulich G, Whiteside DJ, Street D, Fryer TD, Hong YT, Milicevic Sephton S, Aigbirhio FI, O Brien JT, Rowe JB.   +15 more
europepmc   +1 more source

Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and ¹¹C-UCB-J PET study. [PDF]

Front Hum Neurosci, 2023
Fang XT, Volpi T, Holmes SE, Esterlis I, Carson RE, Worhunsky PD.   +5 more
europepmc   +1 more source