Results 31 to 40 of about 1,026 (107)

Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Synaptic density loss has been proposed as a major neuronal mechanism through which cognition degrades in Alzheimer's disease (AD). PET imaging studies have observed synaptic density change across the AD continuum using SV2A radiotracer [11C]UCB‐J.
Max McLachlan, Alexandra H DiFilippo, Brecca Bettcher, Lisette LeMerise, Andrew K McVea, Matthew D Zammit, Sigan L Hartley, Barbara B. Bendlin, Bradley T Christian   +8 more
wiley   +2 more sources

Additional file 14 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 14. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J BPND and R1 against corresponding SRTM estimates separately for all subjects. All the Hammers ROIs were included for this analysis. Regional parametric values from both test and retest scans were pulled together for these comparisons.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +1 more source

Additional file 1 of Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET

, 2022
Additional file 1. Region of interest definition on HRRT PET Images - Top row: Sagittal view of early (0-10 mins) summed baseline (left) and blocking (right) [11C]UCB-J PET uptake images scaled to brain uptake (A) and scaled to spinal cord uptake (B).
Rossano, Samantha, Toyonaga, Takuya, Bini, Jason, Nabulsi, Nabeel, Ropchan, Jim, Cai, Zhengxin, Huang, Yiyun, Carson, Richard E.   +7 more
openaire   +1 more source

Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Synapse loss, a key feature of behavioral variant frontotemporal dementia (bvFTD), can now be visualized in vivo using positron emission tomography (PET) that targets synaptic vesicle glycoprotein 2A (SV2A). Comparing this new imaging method with the clinical standard of glucose metabolism using 18F‐fluorodeocyglucose (18F‐FDG ...
Arman Fesharaki‐Zadeh, Salih Cayir, Waleed Ibrahim, Yanghong Yang, Jean‐Dominique Gallezot, Mika Naganawa, Yanjun Wu, Takuya Toyonaga, Faranak Ebrahimian Sadabad, Ryan O'Dell, Brian Pittman, Nabeel Nabulsi, Stephen Strittmatter, Richard E. Carson, Yiyun Huang, Christopher H. van Dyck, Adam P. Mecca, David Matuskey   +17 more
wiley   +1 more source

Toward Harmonizing Quantification of Dopamine Neuron Imaging Biomarkers in Parkinson's Disease: The Centamine Scale

Annals of Neurology, Volume 99, Issue 4, Page 949-963, April 2026.
Objective Dopaminergic imaging is a key biomarker for both the investigation of the biology of Parkinson's disease and related synucleinopathies and the evaluation of potential therapies in clinical trials. This work presents a harmonized approach for quantifying dopaminergic molecular imaging tracers, such as [123I]ioflupane (dopamine transporter scan
Zhen Fan, Graham Searle, Gaia Rizzo, Justin Albani, Patrick Cella, Robert Comley, Gregory Klein, Luca Passamonti, Cristian Salinas, Adam J. Schwarz, Leonardo Iaccarino, Gilles Tamagnan, Jamie Eberling, Ken Marek, John Seibyl, Roger N. Gunn, The Parkinson's Progression Markers Initiative, Kenneth Marek, Caroline Tanner, Tanya Simuni, Andrew Siderowf, Douglas Galasko, Lana Chahine, Christopher Coffey, Kalpana Merchant, Kathleen Poston, Roseanne Dobkin, Tatiana Foroud, Brit Mollenhauer, Dan Weintraub, Ethan Brown, Karl Kieburtz, Mark Frasier, Todd Sherer, Sohini Chowdhury, Roy Alcalay, Aleksandar Videnovic, Duygu Tosun‐Turgut, Werner Poewe, Susan Bressman, Jan Hammer, Raymond James, Ekemini Riley, John Seibyl, Leslie Shaw, David Standaert, Sneha Mantri, Nabila Dahodwala, Michael Schwarzschild, Connie Marras, Hubert Fernandez, Ira Shoulson, Helen Rowbotham, Paola Casalin, Claudia Trenkwalder, Todd Sherer, Sohini Chowdhury, Mark Frasier, Jamie Eberling, Katie Kopil, Alyssa O'Grady, Maggie McGuire Kuhl, Leslie Kirsch, Tawny Willson, Charles Adler, Roy Alcalay, Amy Amara, Paolo Barone, Bastiaan Bloem, Susan Bressman, Kathrin Brockmann, Norbert Brüggemann, Lana Chahine, Kelvin Chou, Nabila Dahodwala, Alberto Espay, Stewart Factor, Hubert Fernandez, Michelle Fullard, Douglas Galasko, Robert Hauser, Penelope Hogarth, Shu‐Ching Hu, Michele Hu, Stuart Isaacson, Christine Klein, Rejko Krueger, Mark Lew, Zoltan Mari, Connie Marras, Maria Jose Martí, Nikolaus McFarland, Tiago Mestre, Brit Mollenhauer, Emile Moukheiber, Alastair Noyce, Njideka Okubadejo, Sarah O'Shea, Rajesh Pahwa, Nicola Pavese, Werner Poewe, Ron Postuma, Giulietta Riboldi, Lauren Ruffrage, Javier Ruiz Martinez, David Russell, Marie H Saint‐Hilaire, Neil Santos, Wesley Schlett47, Ruth Schneider, Holly Shill, David Shprecher, Tanya Simuni, David Standaert, Leonidas Stefanis, Yen Tai, Caroline Tanner, Arjun Tarakad, Eduardo Tolosa PhD34, Aleksandar Videnovic, Susan Ainscough, Courtney Blair, Erica Botting, Isabella Chung, Kelly Clark, Ioana Croitoru, Kelly DeLano, Iris Egner, Fahrial Esha, May Eshel, Frank Ferrari, Victoria Kate Foster, Alicia Garrido, Madita Grümmer, Bethzaida Herrera, Ella Hilt, Chloe Huntzinger, Raymond James, Farah Kausar, Christos Koros, Yara Krasowski60, Dustin Le, Ying Liu, Taina M. Marques, Helen Mejia Santana, Sherri Mosovsky, Jennifer Mule, Philip Ng, Lauren O'Brien, Abiola Ogunleye, Oluwadamilola Ojo, Obi Onyinanya, Lisbeth Pennente, Romina Perrotti, Michael Pileggi, Ashwini Ramachandran, Deborah Raymond, Jamil Razzaque, Shawna Reddie, Kori Ribb, Kyle Rizer, Janelle Rodriguez, Stephanie Roman, Clarissa Sanchez, Cristina Simonet, Anisha Singh, Elisabeth Sittig, Barbara Sommerfeld, Angela Stovall, Bobbie Stubbeman, Alejandra Valenzuela, Catherine Wandell, Diana Willeke, Karen Williams, Dilinuer Wubuli   +174 more
wiley   +1 more source

Neuroprotection trial design in progressive supranuclear palsy: challenges and solutions

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION We review the specific challenges posed to neuroprotective trial design by progressive supranuclear palsy (PSP), a rare disorder difficult to diagnose and to assess quantitatively. METHODS Focusing on reducing the size and cost of trials, we review elements of PSP neuroprotection trial methodology and formulate a new minimum ...
Lawrence I. Golbe, Ronald G. Thomas
wiley   +1 more source

Tracking early cognitive decline in preclinical AD with brain MRI similarity

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Early detection of neuroanatomical changes in preclinical Alzheimer's disease (AD) is critical for timely intervention. However, conventional magnetic resonance imaging (MRI) and fluid biomarkers often lack sensitivity to subtle structural alterations in early disease stages. METHODS To identify early brain alterations, we applied
Jiawei Sun, Blanca Zufiria‐Gerbolés, Massimiliano Passaretti, Giovanni Volpe, Mite Mijalkov, Joana B. Pereira, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Long‐term forgetting, sleep, and tau in autosomal‐dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Accelerated long‐term forgetting (ALF) may represent one of the earliest cognitive changes in Alzheimer's disease (AD). However, whether ALF emerges in the preclinical stage of autosomal‐dominant AD (ADAD) is unclear, and its underlying mechanisms are poorly understood.
Jason C. You, Alex C. Bender, Courtney Berezuk, Daisy T. Noriega‐Makarskyy, Ana Baena, Diana Munera, Enmanuelle Pardilla‐Delgado, Liliana Ramirez‐Gomez, David Aguillon, Averi Giudicessi, Jairo E. Martinez, Alice Cronin‐Golomb, Alice D. Lam, Yakeel T. Quiroz   +13 more
wiley   +1 more source

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, Volume 17, Issue 1, February 2026.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source

Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This review outlines positron emission tomography (PET) biomarkers used in Alzheimer's disease (AD) research and clinical settings, targeting both specific (amyloid, tau) and non‐specific (neurodegeneration, synaptic density, neuroinflammation) processes.
Elif Harput, Cecilia Boccalini, Gregory Mathoux, John O. Prior, Nathalie Testart, Mario Jreige, Valentina Garibotto   +6 more
wiley   +1 more source