Plasma β‐synuclein associates with hippocampal synaptic density measured with [11C]UCB‐J PET and plasma tau markers in Alzheimer's disease [PDF]
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Plasma β‐synuclein is a promising blood‐based synaptic biomarker, but relationships with synaptic density as indicated by [11C]UCB‐J positron emission tomography (PET), and blood biomarkers of Alzheimer's disease (AD) pathology, neurodegeneration, and astrocyte activation need further characterization.
Darby C Peter +13 more
wiley +2 more sources
Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET [PDF]
EJNMMI Physics, 2022 Abstract Purpose Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI imaging to evaluate injury severity.
Samantha Rossano +7 more
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Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease [PDF]
NeuroImage, 2021 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the combination of gray-matter (GM) atrophy and SV2A decrease in the remaining tissue.
Yihuan Lu +7 more
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Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis [PDF]
NeuroImage, 2021 The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET maps synaptic density via synaptic vesicle protein 2A, which is a more direct structural measure underlying brain ...
Xiaotian T. Fang +11 more
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The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study [PDF]
Imaging NeuroscienceAbstract Synaptic terminal density is thought to influence cognitive function and neural activity, yet its role in cognition has not been explored in healthy humans. We examined these relationships using [11C]UCB-J positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in 25 healthy adults performing ...
Shatalina, E. +14 more
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Automated GMP production and long-term experience in radiosynthesis of the SV2A tracer [11C]UCB-J [PDF]
EJNMMI Radiopharmacy and ChemistryAbstract Background Positron emission tomography (PET) is a non-invasive imaging technique that enables the quantification of specific biological and pharmacological processes in vivo.
Saara Wahlroos +5 more
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S13. IN VIVO EVIDENCE OF REDUCED SYNAPTIC VESICLE DENSITY IN SCHIZOPHRENIA USING [11C] UCB-J PET IMAGING [PDF]
Schizophrenia Bulletin, 2019 Rajiv Radhakrishnan +9 more
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, 2022 Additional file 18. TRT (%) values estimated for specific brain regions (grey matter) are presented for RPM BPND and R1.
Tuncel, Hayel +20 more
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, 2022 Additional file 15. The % bias (mean + SD) estimated for the parametric methods of interest against corresponding SRTM estimates using 60 minutes data.
Tuncel, Hayel +20 more
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Apathy in Lewy Body Disorders: A Position Paper
Movement Disorders, EarlyView.Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source