Results 1 to 10 of about 1,026 (107)

Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET [PDF]

EJNMMI Research, 2022
Abstract[11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy and the 28-day test–retest repeatability (TRT) of various parametric quantitative methods for dynamic ...
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David V. llez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., de Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
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In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2020
The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located in secretory vesicles. We aimed to assess [11C]UCB-J PET as an in vivo biomarker of regional cerebral synaptic SV2A density in rat lesion
Majken B Thomsen, Jan Jacobsen, Thea P Lillethorup, Anna C Schacht, Mette Simonsen, Marina Romero-Ramos, David J Brooks, Anne M Landau   +7 more
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Potential of [11C]UCB-J as a PET tracer for islets of Langerhans [PDF]

Scientific Reports, 2021
AbstractBiomarkers for the measurement of islets of Langerhans could help elucidate the etiology of diabetes. Synaptic vesicle glycoprotein 2 A (SV2A) is a potential marker reported to be localized in the endocrine pancreas. [11C]UCB-J is a novel positron emission tomography (PET) radiotracer that binds to SV2A and was previously evaluated as a ...
Puuvuori E, Rokka J, Carlsson PO, Li Z, Eriksson J, Eriksson O   +5 more
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Improved synthesis of SV2A targeting radiotracer [11C]UCB-J [PDF]

EJNMMI Radiopharmacy and Chemistry, 2019
Abstract Introduction [ 11 C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of ...
Johanna Rokka, Eva Schlein, Jonas Eriksson   +2 more
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Identification of pre-synaptic density networks using [11C]UCB-J PET imaging and ICA in mice

NeuroImage, 2022
Synaptic vesicle glycoprotein 2A (SV2A) is a vesicle glycoprotein involved in neurotransmitter release. SV2A is located on the pre-synaptic terminals of neurons and visualized using the radioligand [11C]UCB-J and positron emission tomography (PET) imaging. Thus, SV2A PET imaging can provide a proxy for pre-synaptic density in health and disease.
Jordy Akkermans, Franziska Zajicek, Alan Miranda, Mohit H. Adhikari, Daniele Bertoglio   +4 more
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Synaptic vesicle protein SV2A imaging with [11C]UCB‐J as a novel biomarker of neurodegeneration in Alzheimer's disease [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundSynaptic loss is a known feature of symptomatic Alzheimer’s disease (AD). Conversely, abundance of synapses may confer resilience to cognitive decline in the presence of AD pathology. Currently, the extent and distribution of synapse loss during the asymptomatic stages of AD is unknown. Synaptic vesicle glycoprotein 2A (SV2A) is found
Barbara B Bendlin, Alexandra H DiFilippo, Tobey J Betthauser, Nathaniel A Chin, Dhanabalan Murali, Nicholas M Vogt, Grace McKinney, Nancy J Davenport, Todd E Barnhart, Jonathan W Engle, Sterling C Johnson, Bradley T Christian   +11 more
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Automated Radiosynthesis of [11C]UCB-J for Imaging Synpatic Density by PET

, 2020
An automated radiosynthesis of carbon-11 PET radiotracer [11C]UCB-J for imaging the synaptic density biomarker synaptic vesicle glycoprotein SV2A was established using Synthra RNPlus synthesizer. Commercially available trifluoroborate UCB-J analogue was used as a radiolabelling precursor and the desired radiolabelled product was isolated in 11 ± 2% (n =
Milicevic Sephton, Selena, Miklovicz, Tunde, Russell, Joseph J, Doke, Aniruddha, Li, Lei, Boros, Istvan, Aigbirhio, Franklin I   +6 more
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Additional file 12 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 12. The % bias (mean + SD) estimated for the parametric methods of interest against corresponding 1T2k_VB estimates using 60 minutes data.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
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Additional file 19 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 19. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J VT, K1 and BPND against corresponding 1T2k_VB estimates for HCs using 90 minutes data. All the Hammers ROIs were included for this analysis.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
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Additional file 13 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 13. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J VT, K1 and BPND against corresponding 1T2k_VB estimates separately for all subjects. All the Hammers ROIs were included for this analysis. Regional parametric values from both test and retest scans were pulled together for these comparisons.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +1 more source