Results 91 to 100 of about 2,347 (126)

Additive Capacity of [6]-Shogaol and Epicatechin To Trap Methylglyoxal

Journal of Agricultural and Food Chemistry, 2017
Methylglyoxal (MGO), a reactive dicarbonyl species, is thought to contribute to the development of long-term pathological diabetes as a direct toxin or as an active precursor of advanced glycation end products (AGEs). Trapping MGO by dietary phenols to inhibit the MGO induced AGE formation is an approach for alleviating diabetic complications.
Qiju Huang, Pei Wang, Yingdong Zhu, Lishuang Lv, Shengmin Sang   +4 more
openaire   +2 more sources

Ginger (Gingerols and 6-Shogaol) Against Cancer

2021
Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), is one of the most widely consumed spices worldwide due to its pungent smell and taste. It has also traditionally been used since antiquity for the treatment of ailments like common colds, fever, arthritis, rheumatism, gastrointestinal complications, motion sickness, diabetes ...
Esra Köngül Şafak, Gökçe Şeker Karatoprak   +1 more
openaire   +1 more source

Interindividual Variability in Metabolism of [6]-Shogaol by Gut Microbiota

Journal of Agricultural and Food Chemistry, 2017
[6]-Shogaol (6S), one of the major bioactive components in dry ginger, is attracting considerable attention because of its wide spectrum of biological activities, but its metabolic fate is still not fully understood. In the present study, the microbial metabolism of 6S was examined for the first time in in vitro batch fecal fermentation system and in ...
Pei Wang, Ronghui Wang, Yingdong Zhu, Shengmin Sang   +3 more
openaire   +2 more sources

ESTABLISHMENT OF THE 6-SHOGAOL EXTRACTION PROCESS FROM 6-SHOGAOL-ENRICHED GINGER FOR CANCER TREATMENT

VietNam Military Medical Unisversity
Objectives: To optimally extract the potential phytochemical “6-shogaol” from fermented shogaol-enriched ginger. Methods: Extraction process parameters were investigated using 6-shogaol as a marker. Results: The suitable parameters of the 6-shogaol extraction process: Hot extraction using reflux equipment, solvent of 90% ethanol, solvent/herb ratio of ...
Ba Ngoc Minh Ho, Trong Diep Nguyen, Van Hien Pham, Binh Duong Vu   +3 more
openaire   +1 more source

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

International Journal of Developmental Neuroscience, 2021
AbstractObjective6‐Shogaol, bioactive compound of Zingiber officinale Roscoe, has anti‐inflammatory, antioxidant, and neuroprotective properties. The objective of the present study was to verify the effect of 6‐shogaol on behavioral parameters in a preclinical model based on a maternal immune activation (MIA) by lipopolysaccharide (LPS ...
Naiana da Rosa, Fabiana Durante de Medeiros, Juliana de Oliveira, Ana Olívia Martins Laurentino, Eduardo Medeiros Peretti, Richard Simon Machado, Jucélia Jeremias Fortunato, Fabrícia Petronilho   +7 more
openaire   +2 more sources

Biotransformation of 6-gingerol and 6-shogaol by Aspergillus niger

Phytochemistry, 1993
Abstract 6-Gingerol and shogaol, the pungent constituents of Zingiber officinalis were biotransformed by Aspergillus niger. 6-Gingerol was converted to the corresponding primary alcohol as major product although a keto group is present in the molecule whereas the double bond and keto group of 6-shogaol were reduced and the terminal methyl group was ...
Hironobu Takahashi, Toshihiro Hashimoto, Yoshiaki Noma, Yoshinori Asakawa   +3 more
openaire   +1 more source

6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

Neuropharmacology, 2012
Inflammatory processes in the central nervous system play an important role in a number of neurodegenerative diseases mediated by microglial activation, which results in neuronal cell death. Microglia act in immune surveillance and host defense while resting.
Sang Keun, Ha, Eunjung, Moon, Mi Sun, Ju, Dong Hyun, Kim, Jong Hoon, Ryu, Myung Sook, Oh, Sun Yeou, Kim   +6 more
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Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids

Journal of Pharmaceutical and Biomedical Analysis, 2007
The degradation kinetics of [6]-gingerol and [6]-shogaol were investigated in simulated gastric (pH 1) and intestinal (pH 7.4) fluids at 37 degrees C. Degradation products were quantitatively determined by HPLC (Lichrospher 60 RP select B column, 5 microm, 125 mm x 4 mm; mobile phase: methanol-water-acetic acid (60:39:1 v/v); flow rate: 0.6 ml/min ...
Sushila, Bhattarai, Van H, Tran, Colin C, Duke   +2 more
openaire   +2 more sources

The therapeutic potential of naturally occurring 6-shogaol: an updated comprehensive review

Inflammopharmacology
Abstract Shogaol, a significant bioactive constituent of ginger, is present in several forms, including 4-, 6-, 8-, 10-, and 12-shogaol, with 6-shogaol identified as the most potent among them. Notably, 6-shogaol can be metabolized into 6-paradol, a compound that lacks pungency but retains biological activity. The primary focus of this review
Mai A Abd-Elmawla, Riham A El-Shiekh, Kareem Attallah   +2 more
exaly   +3 more sources

Digestive functions regulated by 6-shogaol towards stomach and small intestine

2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2017
Ginger is a well-known traditional Chinese medicine which has been identified with positive digestive function regulations e.g. vomit prevention and warming interior. 6-shogaol is one of ginger's major bioactive constituents. In this study, digestive functions regulated by 6-shogaol towards stomach and small intestine were investigated.
Guang Zheng, Nannan Wang, Hongtao Guo
openaire   +2 more sources