Results 81 to 90 of about 2,347 (126)

Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats. [PDF]

Front Pharmacol
Songvut P, Nakareangrit W, Cholpraipimolrat W, Kwangjai J, Worasuttayangkurn L, Watcharasit P, Satayavivad J.   +6 more
europepmc   +1 more source

Protective effect of 6-shogaol against endotoxin-induced periodontitis in rats

Acta Poloniae Pharmaceutica - Drug Research, 2018
HongYan Qi, Bing Han
openaire   +1 more source

6-shogaol against 3-Nitropropionic acid-induced Huntington's disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway. [PDF]

PLoS One
Jambi EJ, Alamri A, Afzal M, Al-Abbasi FA, Al-Qahtani SD, Almalki NAR, Bawadood AS, Alzarea SI, Sayyed N, Kazmi I.   +9 more
europepmc   +1 more source

Cytoprotective and Anti-inflammatory Effects of 6-Shogaol on Human Dermal Fibroblasts

Asian Journal of Beauty and Cosmetology, 2017
Na-Kyeong Lee, Jung-Eun Ku, Hyo Sun Han
openaire   +1 more source

6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress. [PDF]

Molecules
Yang AY, Kim K, Kwon HH, Leem J, Song JE.   +4 more
europepmc   +1 more source

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Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity

Food Chemistry, 2023
This study investigated the ability of 6-shogaol to reduce obesity in C57BL/6J mice fed with high-fat diet (HFD). After 12 weeks of 6-shogaol (20, 40, 60 mg/kg/2 days) intervention, obesity related indicators, gut microbiota and metabonomics of mice were analyzed. The obesity degree and blood lipid level of mice treated with 6-shogaol were reduced, and
Xianghong Wang
exaly   +3 more sources

Investigating the Anti-Cancer Properties of 6-Shogaol in Zingiber officinale

Critical Reviews™ in Oncogenesis, 2022
Cancer is ranked as the first or second cause of death in 112 countries across the world with an estimated 19.3 million new cases of cancer along with 10 million deaths occurring in 2020. Colon cancer is the second most common cancer in women and the fourth most common cancer worldwide.
Sowsan, Hafuth, Sukhpal, Randhawa
openaire   +2 more sources

Occurrence, biological activity and metabolism of 6-shogaol

Food & Function, 2018
As one of the main bioactive compounds of dried ginger, 6-shogaol has been widely used to alleviate many ailments.
Xingran Kou, Xiaoqi Wang, Ruya Ji, Lang Liu, Yening Qiao, Zaixiang Lou, Chaoyang Ma, Shiming Li, Hongxin Wang, Chi-Tang Ho   +9 more
openaire   +2 more sources

Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells

Molecular Biology Reports, 2021
Chronic Myeloid Leukemia (CML) is a clonal hematopoietic malignancy characterized by the formation of BCR-ABL fusion protein. Imatinib (IMA) is a BCR-ABL tyrosine kinase inhibitor (TKI), which exhibited a high rate of response for newly diagnosed CML patients. Emergence of IMA resistance considered as a major challenge in CML therapy.
Tulin Ozkan, Yalda Hekmatshoar, Hanife Pamuk, Merve Ozcan, Guler Yaman, Gulsah Ceylan Yagiz, Cigdem Akdemir, Asuman Sunguroglu   +7 more
openaire   +2 more sources

Glucuronidation and its impact on the bioactivity of [6]-shogaol

Molecular Nutrition & Food Research, 2017
-shogaol (6S) from ginger has been reported to have diverse bioactivities and can be widely metabolized in animals and humans; however, the impact of glucuronidation on its bioactivity is still largely unknown. This study investigates the glucuronidation of 6S and its effect on cell cytotoxicity and Nrf2-inducing activities of 6S.The glucuronidated ...
Pei, Wang, Yantao, Zhao, Yingdong, Zhu, Shengmin, Sang   +3 more
openaire   +2 more sources