Results 211 to 220 of about 132,552 (240)
ATR dependent activation of Chk2
Journal of Cellular Physiology, 2006 AbstractATM and ATR are essential regulators of DNA damage checkpoints in mammalian cells through their respective effectors, Chk2 and Chk1. Cross regulation of the ATM‐Chk2 and ATR‐Chk1 pathways is very limited, although ATM and ATR show overlapping function in a partnership and time‐dependent manner.
Wang, XQ +3 more
openaire +5 more sources
Mouse models for ATR deficiency
DNA Repair, 2009 ATM and ATR orchestrate overlapping DNA damage responses in reply to different forms of DNA strand discontinuities. But, knockout mouse models suggest that ATR is essential for viability in contrast to ATM. Recently, more sophisticated mouse models have been published including a conditional ATR-knockdown system and by modelling the human ATR-Seckel ...
Mark O’Driscoll +1 more
core +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2005
One of the central problems in Automated Target Recognition is to accommodate the infinite variety of clutter in real military environments. The principle focus of our paper is on the construction of metric spaces where the metric measures the distance between objects of interest invariant to the infinite variety of clutter. Such metrics are formulated
Dmitri Bitouk +2 more
openaire +2 more sources
One of the central problems in Automated Target Recognition is to accommodate the infinite variety of clutter in real military environments. The principle focus of our paper is on the construction of metric spaces where the metric measures the distance between objects of interest invariant to the infinite variety of clutter. Such metrics are formulated
Dmitri Bitouk +2 more
openaire +2 more sources
Nature Reviews Cancer, 2018
The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic.
Lecona E, Fernandez-Capetillo O
openaire +4 more sources
The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic.
Lecona E, Fernandez-Capetillo O
openaire +4 more sources
SPIE Proceedings, 2008
The purpose of the Automatic Target Recognition (ATR) Center is to develop an environment conducive to producing theoretical and practical advances in the field of ATR. This will be accomplished by fostering intellectual growth of ATR practitioners at all levels.
Gregory Arnold +4 more
openaire +1 more source
The purpose of the Automatic Target Recognition (ATR) Center is to develop an environment conducive to producing theoretical and practical advances in the field of ATR. This will be accomplished by fostering intellectual growth of ATR practitioners at all levels.
Gregory Arnold +4 more
openaire +1 more source
Targeting ATR in Cancer Medicine
2023As a key component of the DNA Damage Response, the Ataxia telangiectasia and Rad3-related (ATR) protein is a promising druggable target that is currently widely evaluated in phase I-II-III clinical trials as monotherapy and in combinations with other rational antitumor agents, including immunotherapy, DNA repair inhibitors, chemo- and radiotherapy ...
Carolina, Salguero +4 more
openaire +2 more sources
Diachronica, 2006
Jumjum, a Western Nilotic language, has an eight-vowel system divided into two sets by the feature [ATR] (Advanced Tongue Root), which is the basis of vowel harmony. A comparison with other Western Nilotic languages shows that (i) this vowel system goes back to a ten-vowel system in Proto-Western Nilotic (PWN), (ii) PWN high [−ATR] vowels have become ...
openaire +2 more sources
Jumjum, a Western Nilotic language, has an eight-vowel system divided into two sets by the feature [ATR] (Advanced Tongue Root), which is the basis of vowel harmony. A comparison with other Western Nilotic languages shows that (i) this vowel system goes back to a ten-vowel system in Proto-Western Nilotic (PWN), (ii) PWN high [−ATR] vowels have become ...
openaire +2 more sources
ATR Inhibitors and Paclitaxel in Melanoma
Clinical Cancer Research, 2021Abstract A phase I study defined a tolerable combination of the ATR inhibitor ceralasertib with paclitaxel and responses were seen in patients with melanoma who had progressed on an immune checkpoint inhibitor. This combination warrants further exploration to determine the extent and molecular determinants of clinical activity.
openaire +2 more sources