Results 41 to 50 of about 2,396,283 (252)

Content of trans- and cis-iso-alpha-bitter acids as indicator of sensorial beer stability.

Kvasný průmysl, 2007
Content of cis- a trans- isomers of iso-α-bitter acids has been studied during beer storage at 8 °C, 20 °C and 30 °C. Stereoisomers of iso-α-bitter acids have been determined in beers by optimised method based on Harms and Nitzsche method.
Lenka STRAKOVÁ, Pavel HOFTA, Pavel DOSTÁLEK, Pavel PRŮCHA   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

Advanced Science
Unnatural α‐amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in ...
Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan   +5 more
doaj   +1 more source

Evaluation of α- and β-bitter Acids Content in Harvest of Czech Hops in 2016

Kvasný průmysl, 2017
The contents of α- and β-bitter acids from hops harvested in the Czech Republic in 2016 have been evaluated. Samples originated from all growing areas – Žatec, Úštěk and Tršice (77.3%, 10.7% and 11.9% of the hop garden areas in the Czech Republic).
Alexandr Mikyška, Martin Dušek, Marie Jurková   +2 more
doaj   +1 more source

Stereoselective synthesis of acyclic α,α-disubstituted α-amino acids derivatives from amino acids templates

, 2020
The most important and available references have been collected in this review to prove the versatility of stereoselective synthesis of acyclic α,α-disubstituted α-amino acids from amino acids template equivalents.The authors gratefully acknowledge ...
Ordóñez, Mario, Cativiela, Carlos, Viveros-Ceballos, José Luis   +2 more
core   +1 more source

Synthesis and properties of new chiral heterocyclic peptide mimetics [PDF]

, 2008
The synthesis of tetrahydrofuran C(alpha)-tetrasubstituted amino acids (TAAs) and their effect on the conformation in small peptides are reported. The synthesis starts from the protein amino acid methionine, which is protected at the C and N terminus and
Maity, Prantik
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source