Results 41 to 50 of about 682,713 (259)

Content of trans- and cis-iso-alpha-bitter acids as indicator of sensorial beer stability.

Kvasný průmysl, 2007
Content of cis- a trans- isomers of iso-α-bitter acids has been studied during beer storage at 8 °C, 20 °C and 30 °C. Stereoisomers of iso-α-bitter acids have been determined in beers by optimised method based on Harms and Nitzsche method.
Lenka STRAKOVÁ, Pavel HOFTA, Pavel DOSTÁLEK, Pavel PRŮCHA   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A study of dynamics of bitter acids and xanthohumol in hop pellets during storage [PDF]

, 2018
ArticleEight varieties of hop pellets were analyzed for the contents of α - acids, ß - acids and xanthohumol according to the EBC 7.7 analytical method. The pellets were extracted with acidified mixture methanol - diethylether and
Chládek, L., Hejtmánková, A., Hlavatá, E., Táborský, J.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract [PDF]

, 2018
Hop-derived compounds have been subjected to numerous biomedical studies investigating their impact on a wide range of pathologies. Isomerised bitter acids (isoadhumulone, isocohumulone and isohumulone) from hops, used in the brewing process of beer, are
Cicek, Serhat Sezai, Hintzpeter, Jan, Martin, Hans-Jörg, Maser, Edmund, Seliger, Jan Moritz, Witt, Lydia T   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

Advanced Science
Unnatural α‐amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in ...
Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluation of α- and β-bitter Acids Content in Harvest of Czech Hops in 2016

Kvasný průmysl, 2017
The contents of α- and β-bitter acids from hops harvested in the Czech Republic in 2016 have been evaluated. Samples originated from all growing areas – Žatec, Úštěk and Tršice (77.3%, 10.7% and 11.9% of the hop garden areas in the Czech Republic).
Alexandr Mikyška, Martin Dušek, Marie Jurková   +2 more
doaj   +1 more source