Results 71 to 80 of about 682,713 (259)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Isolation of individual hop iso-α-acids stereoisomers by β-cyclodextrin. [PDF]
, 2010 Individual iso-α-acids that are responsible for the bitter taste of beer need to be isolated because these acids are required as reference standards in quantitative analysis and when studying the parameters which effect the quality of beer.
Khatib, Alfi +3 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Журнал органічної та фармацевтичної хімії, 2019 Aim. To develop the preparative method for the synthesis of optically active α-amino-α-polyfluoroalkyl-γ-oxobutylphosphonic acids as new promising chiral building blocks. Results and discussion.
O. V. Stanko +3 more
doaj +1 more source
Effect of curing conditions and harvesting stage of maturity on Ethiopian onion bulb drying properties [PDF]
, 2019 The study was conducted to investigate the impact of curing conditions and harvesting stageson the drying quality of onion bulbs. The onion bulbs (Bombay Red cultivar) were harvested at three harvesting stages (early, optimum, and late ...
Adgo, Enyew +8 more
core +1 more source
The effects of hops (Humulus lupulus L.) and silymarin on performance and health of newly weaned pigs [PDF]
, 2007 The ban of antimicrobial growth promoters in pig production has resulted in an increased interest in investigating the effects of different alternatives, which can reduce the problems post weaning and improve the performance in piglets.
Williams, Jeanne
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids
Nature Communicationsα,α-Disubstituted α-amino acids (α-AAs) have improved properties compared to other types of amino acids. They serve as modifiers of peptide conformation and as precursors of bioactive compounds.
Yu Zhang +3 more
doaj +1 more source
Influence of the hopping technology on the storage-induced appearance of staling aldehydes in beer [PDF]
, 2010 J. Inst. Brew. 116(4), 381-398, 2010 In this paper, the involvement of iso-alpha-acids in the appearance of stale flavour in beer during storage was examined.
Aerts, Guido +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source