Results 1 to 10 of about 88 (70)

Degradation kinetics of α‐conotoxin TxID [PDF]

FEBS Open Bio, 2019
α‐Conotoxin (CTx) TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that has been suggested as a potential drug candidate to treat addiction and small cell lung cancer.
Pan Xu, Yang Xiong, Yiqiao Liu, Shurun Yu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +3 more sources

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID [PDF]

Marine Drugs, 2023
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo   +7 more
doaj   +2 more sources

Fluorescently Labeled α-Conotoxin TxID, a New Probe for α3β4 Neuronal Nicotinic Acetylcholine Receptors [PDF]

Marine Drugs, 2022
Neuronal nicotinic acetylcholine receptors (nAChRs) are important ion channel membrane proteins that are widely distributed in the central nervous system (CNS) and peripheral nervous system (PNS).
Meiling Huang, Xiaopeng Zhu, Yishuai Yang, Yao Tan, Sulan Luo, Dongting Zhangsun   +5 more
doaj   +2 more sources

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]

Marine Drugs, 2020
Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li, Shen You, Jian Xiong, Yamin Qiao, Jinpeng Yu, Dongting Zhangsun, Sulan Luo   +6 more
doaj   +2 more sources

DSPE-PEG Modification of α-Conotoxin TxID [PDF]

Marine Drugs, 2019
In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time. The reaction
Weinan Zhao, Yang Xiong, Dongting Zhangsun, Sulan Luo   +3 more
doaj   +2 more sources

Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor [PDF]

Marine Drugs, 2018
α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype.
Jie Ren, Rui Li, Jiong Ning, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +2 more sources

Hippocampal Metabolomics Reveal the Mechanism of α-Conotoxin [S9K]TxID Attenuating Nicotine Addiction [PDF]

Marine Drugs
Nicotine is the main substance responsible for the development of tobacco addiction. The α3β4 nicotinic acetylcholine receptors (nAChRs) are a potential key target for mitigating nicotine reward.
Meiting Wang, Weifeng Xu, Huanbai Wang, Cheng Cui, Rongyan He, Xiaodan Li, Jinpeng Yu, J. Michael McIntosh, Dongting Zhangsun, Sulan Luo   +9 more
doaj   +2 more sources

What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. [PDF]

J Med Chem, 2023
Straub CJ, Rusali LE, Kremiller KM, Riley AP.   +3 more
europepmc   +1 more source

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications. [PDF]

Biomolecules, 2022
Kasheverov I, Kudryavtsev D, Shelukhina I, Nikolaev G, Utkin Y, Tsetlin V.   +5 more
europepmc   +1 more source

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors. [PDF]

Molecules, 2021
Bekbossynova A, Zharylgap A, Filchakova O.   +2 more
europepmc   +1 more source