Results 11 to 20 of about 88 (70)

Cyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity. [PDF]

J Pept Sci
This study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Zhang Y, Tae HS, Adams DJ, Durek T, Craik DJ.   +4 more
europepmc   +2 more sources

Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes. [PDF]

Chemistry
FoldX was benchmarked as the best energy prediction method, and seven accurate molecular models of α‐conotoxin/nAChRs were developed as surrogates for the experimental complexes. The combined use of FoldX and these molecular models emerged as an effective approach to predict α‐conotoxins with improved pharmaceutical properties.
Wu X, Hone AJ, Huang YH, Clark RJ, McIntosh JM, Kaas Q, Craik DJ.   +6 more
europepmc   +2 more sources

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR. [PDF]

Mar Drugs, 2021
Pan S, Fan Y, Zhu X, Xue Y, Luo S, Wang X.   +5 more
europepmc   +1 more source

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy. [PDF]

Mar Drugs, 2022
Wang L, Wu X, Zhu X, Zhangsun D, Wu Y, Luo S.   +5 more
europepmc   +1 more source

Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells. [PDF]

J Neurosci, 2022
Jiménez-Pompa A, Sanz-Lázaro S, Omodolor RE, Medina-Polo J, González-Enguita C, Blázquez J, McIntosh JM, Albillos A.   +7 more
europepmc   +1 more source

Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor. [PDF]

Mar Drugs, 2021
Guo M, Yu J, Zhu X, Zhangsun D, Luo S.
europepmc   +1 more source

Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB. [PDF]

Mar Drugs, 2021
Zhang B, Ren M, Xiong Y, Li H, Wu Y, Fu Y, Zhangsun D, Dong S, Luo S.   +8 more
europepmc   +1 more source

Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. [PDF]

J Med Chem, 2013
Luo S, Zhangsun D, Zhu X, Wu Y, Hu Y, Christensen S, Harvey PJ, Akcan M, Craik DJ, McIntosh JM.   +9 more
europepmc   +1 more source

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists. [PDF]

J Neurochem, 2020
Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A, McIntosh JM.   +7 more
europepmc   +1 more source

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA. [PDF]

Mar Drugs, 2020
Sun Z, Zhangsun M, Dong S, Liu Y, Qian J, Zhangsun D, Luo S.   +6 more
europepmc   +1 more source