Results 91 to 100 of about 921,366 (160)

Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms

Haematologica, 2009
Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells.
Davide Bagnara, Adalberto Ibatici, Mirko Corselli, Nadia Sessarego, Claudya Tenca, Amleto De Santanna, Andrea Mazzarello, Antonio Daga, Renzo Corvò, Giulio De Rossi, Francesco Frassoni, Ermanno Ciccone, Franco Fais   +12 more
doaj   +1 more source

Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids

Communications Chemistry
α-Galactosylceramide (α-GalCer) is a prototypical antigen recognized by natural killer T (NKT) cells, a subset of T cells crucial for immune regulation.
Jesang Lee, Sumin Son, Minha Lee, Seung Bum Park   +3 more
doaj   +1 more source

Conformationally Restricted Analogues of α-Galactosylceramide as Adjuvant in COVID-19 Subunit Vaccine. [PDF]

ACS Med Chem Lett, 2023
Hu X, Xian MY, Wang XF, Zou GQ, Luo R, Peng H, Liu Z.   +6 more
europepmc   +1 more source

Κριτική - Έτος Α' τευχ. 1-12 (15 Ιουνίου 1923 - 30 Μαΐου 1924)

, 1923
Στο Έτος Α’ περιλαμβάνονται 12 ...

core  

Ability of IDO To Attenuate Liver Injury in α-Galactosylceramide–Induced Hepatitis Model

, 2010
IDO converts tryptophan to l-kynurenine, and it is noted as a relevant molecule in promoting tolerance and suppressing adaptive immunity. In this study, we examined the effect of IDO in α-galactosylceramide (α-GalCer)–induced hepatitis.
Hiroyasu Ito, Yosuke Osawa, Akira Hara, Tetsuya Ishikawa, Hirofumi Ohtaki, Kuniaki Saito, Ayako Taguchi, Kazuki Ando, Mitsuru Seishima, Masato Hoshi, Hisataka Moriwaki   +10 more
core   +1 more source

Characterization of a Glycolipid Synthase Producing α-Galactosylceramide in Bacteroides fragilis. [PDF]

Int J Mol Sci, 2022
Caballé M, Faijes M, Planas A.
europepmc   +1 more source

Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide

, 2008
A number of studies have shown that the natural killer T cell (NKT) ligand α-galactosylceramide (α-GalCer) serves as an adjuvant for various vaccines, including viral vaccines, parasite vaccines and protein vaccines.
Zhang, W, Chen, Z, Yang Song, Chen, A, Gardiner, D, David D. Ho, Huang, Y, Alex Chen, David Gardiner, Yaoxing Huang, Moriya Tsuji, Zhiwei Chen, Sankha Basu, Wenyong Zhang, Deborah Gurner, Basu, S, Ho, DD, Li, X, Tsuji, M, Gurner, D, Xiangming Li, Song, Y   +21 more
core   +1 more source

α-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis

, 2010
Summary Myocarditis is an inflammation of the myocardium which often follows virus infections. Coxsackievirus B3 (CVB3), as a marker of the enterovirus group, is one of the most important infectious agents of virus-induced myocarditis ...
Y Wang, C Y Wu, J Luo, G C Qian, J H Wu, G J Chen, X K Guo, Y Feng, Z J Wang   +8 more
core   +1 more source

Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer

Breast Cancer Research
Background Metastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side effects and poor outcomes, demonstrating the need for effective new treatments.
Adam Nelson, Nichole McMullen, Simon Gebremeskel, Roberto De Antueno, Duncan Mackenzie, Roy Duncan, Brent Johnston   +6 more
doaj   +1 more source

In Vivo Iterative Adjuvant Screening Identifies an Intranasal Vaccine Formulation for Elicitation of Protective Mucosal Immune Responses Against SARS-CoV-2

Pharmaceutics
Background: Intranasal (I.N.) vaccination holds promise to elicit mucosal immunity that counters respiratory pathogens at the site of infection. For subunit protein vaccines, immunostimulatory adjuvants are typically required.
Yang Jiao, Sara H. Mahmoud, Chengjin Ye, Yuan Luo, Wei-Chiao Huang, Qinzhe Li, Shiqi Zhou, Yiting Song, Moriya Tsuji, Luis Martinez-Sobrido, Jonathan F. Lovell   +10 more
doaj   +1 more source