Results 81 to 90 of about 921,366 (160)

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity.
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Dale I. Godfrey, Antje Blumenthal   +16 more
doaj   +1 more source

A Concise Synthesis of O-6 and Hydroxylated Analogues of α-Galactosylceramide from D-Lyxose

, 2014
α-Galactosylceramides (α-GalCers)系列化合物因其具重要的免疫調節特，在近幾年來受到關注，並有許多相關合成方法陸續被提出。我們以D-來蘇醣衍生物做為起始物，經九步驟與六步驟得到α-Galactosylceramide O-6衍生物與α-Galactosylceramide 羥基化衍生物，總產率為7%-29%與10%-18%。α-Galactosylceramides are well known as immunostimulating agents having ...
陳吉川, Chen, Ji-Chuan
core  

Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice

Scientific Reports, 2018
Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis.
Takahiro Uchida, Hiroyuki Nakashima, Akira Yamagata, Seigo Ito, Takuya Ishikiriyama, Masahiro Nakashima, Shuhji Seki, Hiroo Kumagai, Naoki Oshima   +8 more
doaj   +1 more source

Depletion of Thymus-Derived CD4+CD25+ T Cells Abrogates the Suppressive Effects of α-galactosylceramide Treatment on Experimental Allergic Conjunctivitis

Allergology International, 2008
Background: We showed previously that α-galactosylceramide (α-GalCer) treatment elevated splenic CD4+ CD25+Foxp3+ T-cell numbers and suppressed the development of experimental allergic conjunctivitis (EC).
Atsuki Fukushima, Tamaki Sumi, Waka Ishida, Ayako Ojima, Minako Kajisako, Hisayuki Ueno, Osamu Taguchi   +6 more
doaj   +1 more source

Activation mechanisms of invariant natural killer T cells (iNKTs)

Iatreia, 2016
A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d molecule.
Baena, Andrés, Gómez-Giraldo, Lina, Carreño, Leandro J.   +2 more
doaj   +1 more source

The mechanism of development of acute lung injury in lethal endotoxic shock using α-galactosylceramide sensitization

, 2008
Summary The mechanism underlying acute lung injury in lethal endotoxic shock induced by administration of lipopolysaccharide (LPS) into α-galactosylceramide (α-GalCer)-sensitized mice was studied.
N Koide, F Hassan, Y Naiki, T Yokochi, I Mori, S Islam, A Morikawa, T Yoshida, G Tumurkhuu, J Dagvadorj   +9 more
core   +1 more source

α-Galactosylceramide–Induced Airway Eosinophilia Is Mediated through the Activation of NKT Cells

, 2011
Invariant NKT (iNKT) cells bridge innate and adaptive immune responses, resulting in the expansion of Ag-specific B and T cell responses. α-Galactosylceramide (α-GalCer), the most studied glycolipid that activates iNKT cells, has been proposed to be an ...
Bor-Luen Chiang, Ya-Hui Chuang, Tzu-Chun Wang, Hsiao-Yu Jen, Alice L. Yu   +4 more
core   +1 more source

α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials

Frontiers in Immunology, 2019
NKT cells are CD1d-restricted innate-like T cells expressing both T cell receptor and NK cell markers. The major group of NKT cells in both human and mice is the invariant NKT (iNKT) cells and the best-known function of iNKT cells is their potent anti ...
Yingting Zhang, Ryan Springfield, Siyang Chen, Xin Li, Xiaotian Feng, Rosa Moshirian, Rirong Yang, Weiming Yuan   +7 more
doaj   +1 more source

Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy [PDF]

, 2014
Background: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid a-galactosylceramide could ...
C Gravekamp, Jahangir, A., Singh, M., Ng, T. W., Sharma-Kharkwal, S., Porcelli, S. A., M M Venkataswamy, Venkataswamy, M. M., T W Ng, S Sharma-Kharkwal, Quispe-Tintaya, W., Gravekamp, C., D Chandra, Carreño, L. J., W Quispe-Tintaya, A Jahangir, M Singh, Chandra, D., L J Carreño, S A Porcelli   +19 more
core   +1 more source

Efficient Production of Functional Human NKT Cells from Induced Pluripotent Stem Cells − Reprogramming of Human Vα24+iNKT Cells

Bio-Protocol, 2017
Antigen-specific T cell-derived induced pluripotent stem cells (iPSCs) have been shown to re-differentiate into functional T cells and thus provide a potential source of T cells that could be useful for cancer immunotherapy. Human Vα24+ invariant natural
Daisuke Yamada, Tomonori Iyoda, Kanako Shimizu, Yusuke Sato, Haruhiko Koseki, Shin-ichiro Fujii   +5 more
doaj   +1 more source