Results 61 to 70 of about 921,366 (160)

The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development

European Journal of Immunology, Volume 56, Issue 5, May 2026.
YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze, Laura Knop, Nouria Jantz‐Naeem, Vladyslava Dovhan, Stephan Fricke, Sascha Kahlfuß, Thomas Schüler, Ursula Bommhardt   +7 more
wiley   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide [PDF]

, 2023
Invariant Natural Killer T cells (iNK-T cells) are a powerful regulatory immune cell that can recruit both innate and adaptive immune cells. Unlike conventional T cells (CD4+ and CD8α+), they recognize glycolipid antigens via the MHC-class-I like ...
Flegle, Alexandra S
core   +1 more source

Development of a novel mechanism-based glycolipid adjuvant for vaccination [version 1; referees: 4 approved]

F1000Research, 2018
The inability to elicit strong and durable cellular responses is a major obstacle in the development of successful vaccines, in particular those against malaria.
Jordana Grazziela Coelho-dos-Reis, Xiangming Li, Moriya Tsuji   +2 more
doaj   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death

JACC: Basic to Translational Science, 2023
Summary: Doxorubicin (DOX)-induced cardiomyopathy has poor prognosis, and myocardial inflammation is intimately involved in its pathophysiology. The role of invariant natural killer T (iNKT) cells has not been fully determined in this disease.
Masashi Sada, MD, Shouji Matsushima, MD, PhD, Masataka Ikeda, MD, PhD, Soichiro Ikeda, MD, PhD, Kosuke Okabe, MD, PhD, Akihito Ishikita, MD, PhD, Tomonori Tadokoro, MD, PhD, Nobuyuki Enzan, MD, PhD, Taishi Yamamoto, MD, Hiroko Deguchi Miyamoto, MD, PhD, Yoshitomo Tsutsui, MD, Ryo Miyake, MD, Daiki Setoyama, PhD, Dongchon Kang, MD, PhD, Tomomi Ide, MD, PhD, Hiroyuki Tsutsui, MD, PhD   +15 more
doaj   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Integrated Analysis of Gut Microbiota and Metabolome Profiling Reveals the Effects of Feeding Approaches on Infants' Gut Microenvironment

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the gut microenvironment disparities between breastfed and formula‐fed infants at 6 months of age. Through multi‐omics analysis, breastfeeding was shown to establish a distinct ecological imprinting characterized by favorable microbial shifts and down‐regulated pro‐inflammatory arachidonic acid metabolism, thereby ...
Simin Zhu, Wenjuan Tu, Wenting Zhang, Li Qing, Chengan Wang   +4 more
wiley   +1 more source

Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice [PDF]

, 2006
α-Galactosylceramide (α-GalCer) is the prototype compound for studying the presentation of glycolipids on CD1d molecules to natural killer T (NKT) lymphocytes. A single i.v.
Fujii, Shinichiro, Hemmi, Hiroaki, Shimizu, Kanako   +2 more
core   +1 more source

Enhancement of Adjuvant Functions of Natural Killer T Cells Using Nanovector Delivery Systems: Application in Anticancer Immune Therapy

Frontiers in Immunology, 2017
Type I natural killer T (NKT) cells have gained considerable interest in anticancer immune therapy over the last decade. This “innate-like” T lymphocyte subset has the unique ability to recognize foreign and self-derived glycolipid antigens in ...
Reem Ghinnagow, Reem Ghinnagow, Reem Ghinnagow, Reem Ghinnagow, Reem Ghinnagow, Luis Javier Cruz, Elodie Macho-Fernandez, Elodie Macho-Fernandez, Elodie Macho-Fernandez, Elodie Macho-Fernandez, Elodie Macho-Fernandez, Christelle Faveeuw, Christelle Faveeuw, Christelle Faveeuw, Christelle Faveeuw, Christelle Faveeuw, François Trottein, François Trottein, François Trottein, François Trottein, François Trottein   +20 more
doaj   +1 more source