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iScience, 2023 Summary: Invariant Natural Killer T (iNKT) cell activation by α-galactosylceramide (αGC) potentiates cytotoxic immune responses against tumors. However, αGC-induced liver injury is a limiting factor for iNKT-based immunotherapy.
Michelangelo Bauwelz Gonzatti +7 more
doaj +1 more source
, 2014 α-galactosylceramide (α-GalCer) presented by respiratory DCs in the context of CD1d activates pulmonary NKT cells to produce IFN-γ and IL-17, which in turn activate macrophages, neutrophils, and possibly NK cells and epithelial cells. Since NKT cells can
Stoyan Ivanov (340915) +2 more
core +1 more source
Synthesis of NBD-α-galactosylceramide and Its Immunologic Properties
, 2016 A representative α-galactosylceramide (α-GalCer), KRN7000, can activate NKT cells through CD1d molecules, which play an essential role in the generation of the strong antitumor activity of KRN7000.
Teruyuki Sakai (2435098) +2 more
core +1 more source
Role of α-Galactosylceramide-activated Vα14 Natural Killer T Cells in the Regulation of Allergic Diseases [PDF]
, 2007 Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with a ligend, α-galactosylceramide (α-GalCer), and play a crucial role in various immune responses, including allergic reactions.
Chiaki Iwamura +3 more
core +1 more source
Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide [PDF]
, 2003 α-Galactosylceramide (α-GalCer) is a glycolipid that stimulates natural killer T cells to produce both T helper (Th) 1 and Th2 cytokines. This property enables α-GalCer to ameliorate a wide variety of infectious, neoplastic, and autoimmune diseases ...
Schmieg, John +3 more
core +2 more sources
Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster +13 more
wiley +1 more source
Social disruption stress exacerbates alpha-galactosylceramide-induced hepatitis in mice [PDF]
, 2005 Objective: Psychosocial stress has been suggested as a possible aggravating factor in liver diseases, however, the underlying mechanism has yet to be clarified.
Chida, Y, Kubo, C, Sonoda, J, Sudo, N
core
, 2016 Key reactions in a concise synthesis of an α-C-galactosylceramide analogue of KRN7000 include a diastereoselective alkenylalane addition to an N-tert-butanesulfinyl imine and the use of an epoxidation/carbamate ring opening sequence to install the ...
Peter Wipf (134666) +1 more
core +1 more source
Developing an On‐Resin Synthesis of α‐Galactosylceramide‐Peptide Conjugate Vaccines
ChemistryEuropeThe covalent attachment of peptide antigens to the NKT cell agonist, α‐galactosylceramide (αGalCer), generates self‐adjuvanting vaccines that prevent and/or eliminate disease in animal models of cancer and infectious disease.
Dr. Michael A. Meijlink +10 more
doaj +1 more source
Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection. [PDF]
PLoS ONE, 2012 α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent studies have proposed that α-GalCer is an effective adjuvant in vaccination against a range of immune challenges, however its mechanism of action has not ...
Emma C Reilly +5 more
doaj +1 more source