Results 31 to 40 of about 921,366 (160)

Production of α-galactosylceramide by a prominent member of the human gut microbiota. [PDF]

PLoS Biology, 2013
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified.
Laura C Wieland Brown, Cristina Penaranda, Purna C Kashyap, Brianna B Williams, Jon Clardy, Mitchell Kronenberg, Justin L Sonnenburg, Laurie E Comstock, Jeffrey A Bluestone, Michael A Fischbach   +9 more
doaj   +1 more source

Corrigendum: CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond [PDF]

Frontiers in Immunology, 2018
Lisa A. King, Roeland Lameris, Tanja D. de Gruijl, Hans J. van der Vliet, Hans J. van der Vliet   +4 more
doaj   +2 more sources

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Scientific Reports, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines.
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh   +9 more
doaj   +1 more source

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2019
Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer).
Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma, Xiaojing Ma   +13 more
doaj   +1 more source

DataSheet1_Efficient synthesis of α-galactosylceramide and its C-6 modified analogs.docx

, 2022
The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used to favor the α-glycosylation product.
Shuai Meng (589281), Chengli Zong (1349238), Huiting Li (791954), Hongzhao Mao (14173020), Ying Xu (9172), Chao Chen (195669), Tiantian Sun (154175)   +6 more
core   +1 more source

Natural Killer T Cells Are Numerically and Functionally Deficient in Patients with Trauma

Journal of Innate Immunity, 2020
Natural killer T (NKT) cells rapidly produce Th1 and Th2 cytokines such as interferon-γ (IFN-γ) and interleukin (IL)-4. This study examined the frequency and function of NKT cells in trauma patients.
Young-Goun  Jo, Jung-Chul  Kim, Hye-Mi  Jin, Young-Nan  Cho, Seung-Jung  Kee, Yong-Wook Park   +5 more
doaj   +1 more source

A comparative study on roles of natural killer T cells in two diet-induced non-alcoholic steatohepatitis-related fibrosis in mice

Annals of Medicine, 2022
Background Immune responses are important in the progression of non-alcoholic fatty liver disease (NAFLD). Natural killer T (NKT) cells are main components of the innate immune system that modulate immunity.
Shumei Zheng, Wenzhuo Yang, Dongmei Yao, Shanhong Tang, Juanni Hou, Xing Chang   +5 more
doaj   +1 more source

Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. [PDF]

PLoS ONE, 2016
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation, mucus hypersecretion, and emphysema, which lead to reduced lung function and breathlessness.
Cheng-Chiu Tsao, Po-Nien Tsao, Yi-Guang Chen, Ya-Hui Chuang   +3 more
doaj   +1 more source

Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy

Frontiers in Immunology, 2019
The glycosphingolipid α-galactosylceramide (α-GalCer) is a well-described immune activator with strong anti-tumor properties in animal models. It is presented on CD1d and acts by stimulating the invariant, type I, natural killer T (iNKT) lymphocytes to ...
Ying Wang, Saikiran K. Sedimbi, Linda Löfbom, Gurdyal S. Besra, Steven A. Porcelli, Susanna L. Cardell   +5 more
doaj   +1 more source

Presentation_1_Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d.PPTX

, 2019
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Motoshi Suzuki (510968), Gavin F. Painter (215308), Jay A. Berzofsky (6694949), Masaki Terabe (370871), Katharine Clark (7478108), Jing Wang (6206297), Anja Bloom (7478114), Susanna L. Cardell (6412763), Jessica Yau (7478111), David J. Venzon (7478117), Dirk M. Zajonc (125216), Steven A. Porcelli (47915), Lise Pasquet (6884444), Benjamin J. Compton (1716781)   +13 more
core   +1 more source