Results 11 to 20 of about 921,366 (160)

Intra-peritoneal hyperthermia combining α-galactosylceramide in the treatment of ovarian cancer. [PDF]

PLoS ONE, 2013
The purpose of this study was to investigate the anti-tumor effect and potential mechanisms of i.p. hyperthermia in combination with α-galactosylceramide (α-GalCer) for the treatment of ovarian cancer.
Chao-Chih Wu, Yin-Ting Chuang, Yun-Ting Hsu, Jung-Tang Huang, T-C Wu, Chien-Fu Hung, Yuh-Cheng Yang, Chih-Long Chang   +7 more
doaj   +2 more sources

Exogenous Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza

mBio, 2016
Influenza A virus infection can predispose to potentially devastating secondary bacterial infections. Invariant natural killer T (iNKT) cells are unconventional, lipid-reactive T lymphocytes that exert potent immunostimulatory functions.
Adeline Barthelemy, Stoyan Ivanov, Maya Hassane, Josette Fontaine, Béatrice Heurtault, Benoit Frisch, Christelle Faveeuw, Christophe Paget, François Trottein   +8 more
doaj   +2 more sources

Author Correction: α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice. [PDF]

Acta Pharmacol Sin, 2022
This corrects the article "α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice" in volume 41 on page ...
Chen X, Liu J, Liu J, Wang WJ, Lai WJ, Li SH, Deng YF, Zhou JZ, Yang SQ, Liu Y, Shou WN, Cao DY, Li XH.   +12 more
europepmc   +2 more sources

Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d [PDF]

Frontiers in Immunology, 2019
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe   +14 more
doaj   +2 more sources

Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases [PDF]

, 2008
Invariant natural killer T (iNKT) cells constitute an important regulatory arm of the immune system. Defects in the number and activities of iNKT cells have been linked to the development of autoimmune diseases.
Reddington, Faye
core   +7 more sources

Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression. [PDF]

Sci Rep, 2021
Posttransplantation cyclophosphamide (PTCy) has become a popular option for haploidentical hematopoietic stem cell transplantation (HSCT). However, personalized methods to adjust immune intensity after PTCy for each patient’s condition have not been well
Nakamura M, Meguri Y, Ikegawa S, Kondo T, Sumii Y, Fukumi T, Iwamoto M, Sando Y, Sugiura H, Asada N, Ennishi D, Tomida S, Fukuda-Kawaguchi E, Ishii Y, Maeda Y, Matsuoka KI.   +15 more
europepmc   +2 more sources

Synthesis and Immunological Activity of Novel Oligo(ethylene glycol) Analogues of α-Galactosylceramide. [PDF]

ACS Omega, 2022
CD1d-arbitrated activation of i-NKT cells by α-galactosylceramide results in the effective secretion of Th1 and Th2 cytokines, with adjuvanticity skewed toward Th2 immunity.
Pawar MS, Vemireddy S, Sambyal S, Sampath Kumar HM.   +3 more
europepmc   +2 more sources

Immunization with dendritic cells loaded with α-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria [PDF]

FEMS Immunology & Medical Microbiology, 2007
We evaluated the effect of immunization with dendritic cells (DCs) pulsed with alpha-galactosylceramide (alphaGalCer) and listeriolysin O (LLO) 91-99 peptide, a dominant cytotoxic T lymphocyte (CTL) epitope of Listeria monocytogenes by observing the responses of specific CD8(+) T cells and in vivo CTL activity. DCs were pulsed with various combinations
Noriyuki, Enomoto, Toshi, Nagata, Takafumi, Suda, Masato, Uchijima, Yutaro, Nakamura, Kingo, Chida, Hirotoshi, Nakamura, Yukio, Koide   +7 more
openaire   +2 more sources

Thermodynamic and Structural Behavior of α-Galactosylceramide and C6-Functionalized α-GalCer in 2D Layers at the Air-Liquid Interface. [PDF]

Chembiochem, 2020
α-Galactosylceramide (KRN7000) is a ligand for the glycoprotein CD1d that presents lipid antigens to natural killer T cells. Therefore, KRN7000 as well as some modified version thereof have been widely investigated as part of novel immunotherapies.
Brezesinski G, Calow ADJ, Pereira CL, Seeberger PH.   +3 more
europepmc   +2 more sources

Targeting Sphingolipids for Cancer Therapy

Frontiers in Oncology, 2021
Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni, Cristina Mir, Yoelsis Garcia-Mayea, Matilde E. LLeonart, Matilde E. LLeonart   +4 more
doaj   +1 more source