Results 11 to 20 of about 1,551,967 (375)

Identification and Molecular Binding Mechanism of Novel α-Glucosidase Inhibitory Peptides from Hot-Pressed Peanut Meal Protein Hydrolysates

Foods, 2023
Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs ...
Xinyu Yang, Dan Wang, Yangyong Dai, Luping Zhao, Wentao Wang, Xiuzhen Ding   +5 more
doaj   +2 more sources

Anti-α-Glucosidase, SAR Analysis, and Mechanism Investigation of Indolo[1,2-b]isoquinoline Derivatives

Molecules, 2023
To find potential α-glucosidase inhibitors, indolo[1,2-b]isoquinoline derivatives (1–20) were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α-glucosidase inhibitory effects with IC50 values of 3.44 ± 0.36~41.24 ±
Mengyue Li, Lin Li, Li Lu, Xuetao Xu, Jinhui Hu, Jin-Bao Peng   +5 more
doaj   +2 more sources

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro.
Xu-Yang Deng, Jun-Jie Ke, Ying-Ying Zheng, Dong-Li Li, Kun Zhang, Xi Zheng, Jing-Ying Wu, Zhuang Xiong, Pan-Pan Wu, Xue-Tao Xu   +9 more
doaj   +2 more sources

Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase [PDF]

Scientific Reports, 2021
In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a–ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under
Fariba Peytam, Ghazaleh Takalloobanafshi, Toktam Saadattalab, Maryam Norouzbahari, Zahra Emamgholipour, Setareh Moghimi, Loghman Firoozpour, Hamid Reza Bijanzadeh, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Parviz Rashidi Ranjbar, Saeed Karima, Roya Pakraad, Alireza Foroumadi   +13 more
openalex   +2 more sources

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes

ACS Omega, 2023
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in excellent yields by treating 3,5-dibromo-4-hydroxybenzaldehyde, dimedone, ammonium acetate, and ethyl acetoacetate in ethanol solvent.
F. Talab, S. Ullah, Aftab Alam, S. Halim, Najeeb-ur Rehman, Zainab, Mumtaz Ali, A. Latif, Ajmal Khan, A. Al‐Harrasi, Manzoor Ahmad   +10 more
semanticscholar   +1 more source

Optimization and Molecular Mechanism of Novel α-Glucosidase Inhibitory Peptides Derived from Camellia Seed Cake through Enzymatic Hydrolysis

Foods, 2023
In recent years, food-derived hypoglycemic peptides have received a lot of attention in the study of active peptides, but their anti-diabetic mechanism of action is not yet clear.
Yuanping Zhang, Fenghua Wu, Zhiping He, X. Fang, Xingquan Liu   +4 more
semanticscholar   +1 more source

Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors

Scientific Reports, 2023
In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities.
Sara Moghadam Farid, Milad Noori, M. Nazari Montazer, Minoo Khalili Ghomi, Marjan Mollazadeh, Navid Dastyafteh, Cambyz Irajie, K. Zomorodian, S. S. Mirfazli, Somayeh Mojtabavi, M. Faramarzi, B. Larijani, Aida Iraji, Mohammad Mahdavi   +13 more
semanticscholar   +1 more source

Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase

Life, 2022
It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved.
Ina Ćorković, D. Gašo-Sokač, Anita Pichler, J. Šimunović, M. Kopjar   +4 more
semanticscholar   +1 more source

Synthesis and In Vitro α-Amylase and α-Glucosidase Dual Inhibitory Activities of 1,2,4-Triazole-Bearing bis-Hydrazone Derivatives and Their Molecular Docking Study

ACS Omega, 2023
There is an increasing prevalence of diabetes mellitus throughout the world, and new compounds are necessary to combat this. The currently available antidiabetic therapies are long-term complicated and side effect-prone, and this has led to a demand for ...
Imran Khan, W. Rehman, F. Rahim, R. Hussain, Shoaib Khan, Liaqat Rasheed, Mohammed M Alanazi, Ashwag S. Alanazi, M. Abdellattif   +8 more
semanticscholar   +1 more source

Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63

International Journal of Molecular Sciences, 2023
Controlling post-prandial hyperglycemia and hyperlipidemia, particularly by regulating the activity of digestive enzymes, allows managing type 2 diabetes and obesity.
Quentin Haguet, F. Le Joubioux, V. Chavanelle, Hugo Groult, Nathan Schoonjans, C. Langhi, A. Michaux, Y. Otero, N. Boisseau, S. Peltier, P. Sirvent, T. Maugard   +11 more
semanticscholar   +1 more source