Results 41 to 50 of about 1,551,967 (375)

Inhibitory effect of leaf extract of Newbouldia laevis on the metabolic activities of alpha-glucosidase and alpha-amylase

Bangladesh Journal of Pharmacology, 2013
In this study, the effect of ethanol extract of the leaves of Newbouldia laevis on the activity of α-amylase and α-glucosidase was investigated. Inhibitory effect of N. laevis extract on α-glucosidase was tested in vitro using baker's yeast α-glucosidase
Oyetunji T. Kolawole, Musbau A. Akanji
doaj   +1 more source

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

Frontiers in Chemistry, 2022
Coumarin and chalcone, two important kinds of natural product skeletons, both exhibit α-glucosidase inhibitory activity. In this work, coumarin-chalcone derivatives 3 (a∼v) were synthesized, and their α-glucosidase inhibitory activity was screened.
Chun-Mei Hu, Yong-Xin Luo, Wen-Jing Wang, Jian-Ping Li, Meng-Yue Li, Yu-Fei Zhang, Di Xiao, Li Lu, Zhuang Xiong, Na Feng, Chen Li   +10 more
doaj   +1 more source

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Biomolecules, 2021
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose ...
Jirawat Riyaphan, Dinh-Chuong Pham, Max K. Leong, C. Weng   +3 more
semanticscholar   +1 more source

Inhibition activity of α-glucosidase by infusion and ethanol extract of white tea and stevia combination [PDF]

Jurnal Sains Teh dan Kina, 2017
Ethanol extract of white tea and its stevia liquor was observed for α-glukosidase inhibition. The research was divided into some steps;  white tea and stevia combination hedonic sensory test, phytochemical identification, and α-glucosidase inhibition activity.
Elvi Trinoviani, Ai Kholisoh, Nisa Fitriani Ar-Rifa, Ardi Rustamsyah   +3 more
openaire   +1 more source

Docking Sulochrin and Its Derivative as α-Glucosidase Inhibitors of Saccharomyces cerevisiae

Indonesian Journal of Chemistry, 2017
Sulochrin known has activity as inhibitors of α-glucosidase enzyme. Interaction of sulochrin to active site of α-glucosidase enzyme from S. cerevisiae has studied by docking method.
Wening Lestari, Rizna Triana Dewi, Leonardus Broto Sugeng Kardono, Arry Yanuar   +3 more
doaj   +1 more source

Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Level in SD Rats Model [PDF]

, 2013
This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of ...
Apostolidis, Emmanouil, Ha, Kyoung-Soo, Jo, Sung-Hoon, Kim, Jong-Gwan, Kim, Young-Cheul, Kwon, Young-In, Moon, Kyoung-Sik, Oh, Chen-Gum   +7 more
core   +3 more sources

Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors

Journal of Biomolecular Structure and Dynamics, 2021
The underlying cause of many metabolic diseases is abnormal changes in enzyme activity in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and α-glucosidase (α-GLY) is ...
Cüneyt Türkeş, Suleyman Akocak, M. Işık, Nebih Lolak, Parham Taslimi, M. Durgun, I. Gülçin, Yakup Budak, Ş. Beydemir   +8 more
semanticscholar   +1 more source

Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies

Foods, 2023
The α-glucosidase inhibitor is of interest to researchers due to its association with type-II diabetes treatment by suppressing postprandial hyperglycemia. Hesperidin is a major flavonoid in orange fruit with diverse biological properties.
Kumaravel Kaliaperumal, Linyan Zhang, Liangliang Gao, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang   +6 more
doaj   +1 more source

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

Molecules, 2022
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug.
R. Hussain, S. Iqbal, Mazloom Shah, W. Rehman, Shoaib Khan, Liaqat Rasheed, F. Rahim, A. Dera, Sana Kehili, E. Elkaeed, N. Awwad, Majed A. Bajaber, M. Alahmdi, Hamad Alrbyawi, H. Alsaab   +14 more
semanticscholar   +1 more source

Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia

Food Science & Nutrition, 2020
The strategy of reducing carbohydrate digestibility by controlling the activity of two hydrolyzing enzymes (α‐amylase and α‐glucosidase) to control postprandial hyperglycemia is considered as a viable prophylactic treatment of type 2 diabetes mellitus ...
Lingxiao Gong, D. Feng, Tianxi Wang, Yuqing Ren, Yingli Liu, Jing Wang   +5 more
semanticscholar   +1 more source