Results 141 to 150 of about 33,464 (260)

Impact of renal function on antidiabetic drug selection in Japan: A real‐world analysis using the J‐DREAMS database

Journal of Diabetes Investigation, EarlyView.
Using a large Japanese real‐world database, we examined antidiabetic drug selection in first and second therapy stratified by renal function and study period. The earlier initiation of SGLT2 inhibitors and GLP‐1 receptor agonists increased over time, particularly in second therapy, with prescribing patterns increasingly aligned across renal function ...
Masashi Kubota, Mitsuru Ohsugi, Kohjiro Ueki   +2 more
wiley   +1 more source

First Description and Characterisation of Lactococcus garvieae Strains Causing Septicaemic Disease in Farmed Sea Bass (Dicentrarchus labrax; Linnaeus) in Spain

Journal of Fish Diseases, EarlyView.
ABSTRACT This study presents the first description and characterisation of Lactococcus garvieae isolated from diseased European sea bass (Dicentrarchus labrax) farmed in Spain. During autumn 2023, two fish farms were affected by infectious outbreaks causing moderate cumulative fish mortality (5%–10%). Diseased fish showed clinical signs of haemorrhagic
Belén Fouz, Evelyn Carballeda‐Carrasco, Javier Barriga‐Cuartero, Yolanda Torres‐Corral, Álvaro Robles, Carlos Zarza, Ysabel Santos   +6 more
wiley   +1 more source

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata

Journal of Integrative Plant Biology, EarlyView.
Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar‐acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as well as biosynthesis of the bioactive metabolite gastrodin.
Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai   +9 more
wiley   +1 more source

Cell‐type‐specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves

New Phytologist, EarlyView.
Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang, Ilja Bezrukov, Pin‐Jou Wu, Hannah Gauß, Marja Timmermans, Detlef Weigel   +5 more
wiley   +1 more source

Evaluation of banana (Musa sp.) flowers of selected varieties for their antioxidative and anti-hyperglycemic potentials [PDF]

, 2016
Consumption of banana flower as a vegetable is popular among many countries in Southeast Asia. In this study, banana flowers of six different Malaysian cultivars namely, pisang Abu (Musa balbisiana cv P.
Azlan, Azrina, Marikkar, Jalaldeen Mohammed Nazrim, Mohamad Ali, Mohd Shukuri, Salleh, Abu Bakar, Tan, S. J.   +4 more
core  

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim, Keunhwa Kim, Jung Heo, Seung Mo Seo, Sungjun Choung, Hyeonjin Kim, Yuri Choi, Kyungsun Park, Hyejung Yun, Dongha Kim, Eun Song Lee, Junwoo Lee, Smita Mirsyad Warsadiharja, Saet Buyl Lee, Sunkyu Han, Soon Ju Park, Sang‐Gyu Kim   +16 more
wiley   +1 more source

Analisis Penambatan Molekul Senyawa Flavonoid Buah Mahkota Dewa (Phaleria Macrocarpa (Scheff.) Boerl.) Pada Reseptor α-Glukosidase Sebagai Antidiabetes [PDF]

, 2013
Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) merupakan buah yang banyak mengandung flavonoid yang dapat digunakan sebagai obat antidiabetes. Senyawa flavonoid yang berkhasiat antidiabetes pada buah mahkota dewa belum diketahui jenisnya sehingga ...
Rachmania, R. A. (Rizky), Supandi, S. (Supandi), Cristina, F. A. (Frisca)   +2 more
core  

The miR171a‐TaSCL6‐1 Module Acts Downstream of miR164‐Targeted TaNAC21/22 to Regulate Leaf Rust Resistance in Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Wheat leaf rust, caused by Puccinia triticina, poses a significant threat to global wheat production. MicroRNAs (miRNAs) are critical regulators of plant growth, development and stress responses; however, their role in wheat resistance to leaf rust remains poorly understood.
Mengjiao Guo, Shujuan Liu, Yuxue Pan, Yilin Huang, Lingqi Kong, Yinhui Zhang, Haixia Liu, Jian Hou, Hongxia Liu, Xiaoyu Zhang, Xueyong Zhang, Chenyang Hao, Tian Li   +12 more
wiley   +1 more source

Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cassava (Manihot esculenta Crantz) exhibits exceptional tolerance to infertile soils and contains abundant cyanogenic glucosides (CGs). Previous research has indicated that CGs can serve as a significant reservoir of organic nitrogen in plants.
Weitao Mai, Ruxue Bao, Xiaocheng Liu, Mengtao Li, Jinling Zhao, Huaifang Zhang, Yuan Yao, Haiyan Wang, Wenquan Wang, Changying Zeng, Xin Chen   +10 more
wiley   +1 more source

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

Plant, Cell &Environment, EarlyView.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source