Results 141 to 150 of about 33,869 (259)

A systematic review and meta‐analysis of the relative benefit of dual versus single oral hypoglycaemic therapy following diagnosis with type 2 diabetes (T2D)

Diabetic Medicine, EarlyView.
Abstract Introduction Achieving and sustaining target glycated haemoglobin (HbA1c) levels is fundamental in the management of type 2 diabetes (T2D). We here aimed to assess whether initial dual oral therapy outperforms monotherapy in reaching glycaemic targets in patients with treatment‐naive or early‐stage T2D.
Mairead Kelly, Sushant Saluja, Hugh Logan Ellis, Sarah Jamil, Martin B. Whyte, Adrian Heald   +5 more
wiley   +1 more source

Kinetics of inhibitory effect of ethyl acetate leaf fraction of Lecaniodiscus cupanoides on enzymes linked to carbohydrate metabolism: An in vitro assessment [PDF]

, 2017
Background and aims: This study investigates the kinetics of inhibitory activities of ethyl acetate leaf fraction of Lecanodiscus cupanoides ...
Abdullahi Adekilekun, Jimoh., Adedayo, Sanni Muideen., Adewale, Adigun Rasheed., Ayokun-nun, Ajao Abdulwakeel., Yusuf Agbomekhe, Adams.   +4 more
core  

Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims We evaluated the impact of scenario‐based multifactorial control on the 3‐year incidence of fatal/non‐fatal cardiovascular disease (CVD) and associated healthcare costs in Asian patients with type 2 diabetes (T2D). Materials and Methods We applied the validated ‘ABC’ model to simulate the 3‐year impact of attaining multiple treatment ...
Lee‐Ling Lim, Eric S. H. Lau, Juliana N. M. Lui, Linong Ji, A. G. Unnikrishnan, Sirinart Sirinvaravong, Siew‐Pheng Chan, Soo Lim, Andrea O. Y. Luk, Juliana C. N. Chan   +9 more
wiley   +1 more source

Bifidobacterium bifidum G9‐1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open‐Label, Randomized Controlled Trial (Binary STAR Study)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the effects of probiotics Bifidobacterium bifidum G9‐1 (BBG9‐1) on gastrointestinal symptoms in patients with Type 2 diabetes mellitus (T2DM) with diarrhoea or constipation. Materials and Methods In a 12‐week open‐label randomised controlled trial, 100 participants were randomized 1:1 to a control or BBG9‐1 group, with 12 mg ...
Genki Kobayashi, Yoshitaka Hashimoto, Tomoyuki Matsuyama, Noriyuki Kitagawa, Saori Majima, Takafumi Senmaru, Emi Ushigome, Hiroshi Okada, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui   +10 more
wiley   +1 more source

Simplified Switching to Once‐Weekly Insulin Icodec Without an Initial One‐Time Additional Dose Versus Once‐Daily Insulin Glargine U100 in Basal Insulin‐Treated Type 2 Diabetes (ONWARDS 10): A Randomised Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims ONWARDS 10 assessed switching from daily basal insulins to once‐weekly insulin icodec without a one‐time additional dose at first injection. Materials and Methods In this treat‐to‐target, open‐label, 26‐week, phase 3b trial, adults with basal‐insulin‐treated type 2 diabetes (T2D) with glycated haemoglobin [HbA1c] 7.0%–10.0% were ...
Julio Rosenstock, Chantal Mathieu, Joshua Buron Feinberg, Priyanka Rao, Cathrine Scavenius, Alice Y. Y. Cheng   +5 more
wiley   +1 more source

Diabetic foot ulcer‐related amputation is associated with twofold increased risk of cardiovascular disease: A Korean National Health Information Database Study

Journal of Diabetes Investigation, EarlyView.
Data/Design: Nationwide, population‐based longitudinal cohort using the Korean National Health Insurance Service health checkup database (index 2009–2012) with follow‐up through December 31, 2018. Population/Exposure: Adults with diabetes (N = 1,229,689); DFU‐related amputation at baseline (n = 1,486) vs no DFU‐related amputation.
Jinsun Jang, Bong‐Seong Kim, Hye Won Yang, Heejun Son, Dong Yeon Lee, Min Gyu Kyung, Hwan Jun Jae, Saebeom Hur, Sang Wha Kim, Sanghyun Ahn, Kyung‐Do Han, Soo Heon Kwak   +11 more
wiley   +1 more source

Altering the inhibitory kinetics and molecular conformation of maltase by Tangzhiqing (TZQ), a natural α-glucosidase inhibitor. [PDF]

BMC Complement Med Ther, 2020
Li Y, Zhang X, Wang R, Han L, Huang W, Shi H, Wang B, Li Z, Zou S.   +8 more
europepmc   +1 more source

Life‐threatening acute complications persist among individuals with type 1 diabetes in Japan: A nationwide registry‐based cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
Despite insulin therapy, 18.8 and 7.8% of the patients experienced diabetic ketosis and diabetic ketoacidosis, respectively. Furthermore, 12.7 and 28.9% of the participants experienced severe hypoglycemia and hypoglycemic unawareness, respectively. Lower C‐peptide levels were associated with the incidence of these complications.
Daisuke Chujo, Akihisa Imagawa, Junnosuke Miura, Kazuma Takahashi, Toru Kikuchi, Ichiro Horie, Daisuke Yabe, Akira Shimada   +7 more
wiley   +1 more source

Impact of COVID‐19 restrictions and their relaxation on body composition and glycemic control in individuals with glucose intolerance in Japan: A single‐center observational study

Journal of Diabetes Investigation, EarlyView.
This study examined glycemic control, body composition, and lifestyle changes in 221 outpatients with glucose intolerance (GI) in Japan across the pre‐state of emergency (SOE), SOE, and post‐SOE periods. HbA1c increased despite body weight reduction, with progressive muscle loss.
Ami Kobayashi, Yamato Keidai, Takaaki Murakami, Ryo Tsukaguchi, Miharu Fujita, Keiko Wada, Daisuke Yabe   +6 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial

Journal of Diabetes Investigation, EarlyView.
Combining oral sodium‐glucose cotransporter 2 inhibitors with reduced intravitreal injections of anti‐vascular endothelial growth factor showed potential efficacy for mild diabetic macular edema. ABSTRACT Aims To investigate the potential of sodium–glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular
Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote   +6 more
wiley   +1 more source