Results 61 to 70 of about 33,378 (259)

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus [PDF]

, 2009
Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice.
Max Crispin, Veronica T. Chang, David J. Harvey, Raymond A. Dwek, Edward J. Evans, David I. Stuart, E. Yvonne Jones, J. Michael Lord, Robert A. Spooner, Simon J. Davis, Kornfeld, Balaguer, Neusüss, Parodi, Herscovics, Tremblay, Lal, Schachter, Jaeken, Fukuda, Fukuda, Lowe, Green, Paulson, Patnaik, Martinez-Duncker, Hong, Sethuraman, Hoppe, Davis, Davis, Butters, Chang, Stanley, Dwek, Hamilton, Li, Hamilton, Reeves, Gleeson, Hughes, Hughes, Foddy, Paschinger, Aghi, Bebbington, Davis, Aricescu, Durocher, Küster, Börnsen, Harvey, Harvey, Harvey, Harvey, Olsnes, Watson, Spooner, Spooner, Crispin, Crispin, Oh-Eda, Harvey, Domon, Chen, Shah, Moremen, Butler, Choi, Wu, Foulquier   +70 more
core   +2 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Expression, activity, and consequences of biochemical inhibition of α- and β-glucosidases in different life stages of Culex quinquefasciatus.

PLoS ONE, 2023
Mosquitoes have a wide range of digestive enzymes that enable them to utilize requisite blood and sugar meals for survival and reproduction. Sugar meals, typically derived from plant sources, are critical to maintain energy in both male and female ...
Edwin R Burgess, Neil D Sanscrainte, Caitlin E Taylor, Lyle J Buss, Alden S Estep   +4 more
doaj   +1 more source

α-Amylase inhibitors : a review of raw material and isolated compounds from plant source [PDF]

, 2012
Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases ...
Batista, Pérola de Oliveira Magalhães Dias, Sales, Paloma Michelle de, Silveira, Dâmaris, Simeoni, Luiz Alberto, Souza, Paula Monteiro de   +4 more
core   +2 more sources

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

Synthesis and α-Glucosidase Inhibitory Mechanisms of Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Potential Marine Bromophenol α-Glucosidase Inhibitor

Marine Drugs, 2011
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment.
Xiukun Lin, Jianteng Wei, Wei Zhang, Ming Liu   +3 more
doaj   +1 more source

Natural products for the treatment of Type 2 Diabetes Mellitus [PDF]

, 2015
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented
Barrios, José Luis, Francini, Flavio, Schinella, Guillermo Raúl   +2 more
core   +2 more sources

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents

Scientific Reports
In this work, a novel series of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives 5a–n were designed by consideration of the potent α-glucosidase inhibitors containing indole and carboxamide-1,2,3-triazole-N-phenylacetamide moieties ...
Mohammad Hossein Sayahi, Samira Zareei, Mohammad Halimi, Majid Alikhani, Ali Moazzam, Maryam Mohammadi-Khanaposhtani, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Hossein Rastegar, Parham Taslimi, Essam H. Ibrahim, Hamed A. Ghramh, Bagher Larijani, Mohammad Mahdavi   +13 more
doaj   +1 more source