Results 81 to 90 of about 3,332,267 (201)

Enantiospecific synthesis of (R-(+)-α-lipoic acid from D-glucose

, 1986
The first enantiospecific synthesis of natural (R)-(+)-α-lipoic acid in 13 steps starting from D-glucose is ...
Garyali, Kamini, Rama Rao, A. V., Gurjar, Mukund K., Ravindranathan, T.   +3 more
core   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, EarlyView.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats

Journal of Pharmacological Sciences, 2011
The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity.
Masafumi Kumazaki, Hitoshi Ando, Akira Sasaki, Taka-aki Koshimizu, Kentarou Ushijima, Keiko Hosohata, Yasuo Oshima, Akio Fujimura   +7 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy

Basic and Clinical Neuroscience, 2012
Introduction : Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory.
Narges Karimi, Mitra Kamran, Mehrdad Roghani, Tourandokht Baluchnejadmojarad   +3 more
doaj   +2 more sources

Enhanced Degradation of Vinyl Copolymers Based on Lipoic Acid

Journal of Polymer Science, Volume 63, Issue 6, Page 1345-1351, 15 March 2025.
ABSTRACT The introduction of degradable units into the backbone of commodity vinyl polymers represents a major opportunity to address the societal challenge of plastic waste and polymer recycling. Previously, we reported the facile copolymerization of α‐lipoic acid derivatives containing 1,2‐dithiolane rings with vinyl monomers leading to the ...
Yoichi Okayama, Parker Morris, Kaitlin Albanese, Sarah Olsen, Atsunori Mori, Javier Read de Alaniz, Christopher M. Bates, Craig J. Hawker   +7 more
wiley   +1 more source

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite

Parasites & Vectors, 2017
Background Lipoic acid is a cofactor for α-keto acid dehydrogenase system that is involved in the central energy metabolism. In the apicomplexan parasite, Plasmodium, lipoic acid protein ligase 1 (LplA1) and LplA2 catalyse the ligation of acquired lipoic
Min Wang, Qiong Wang, Xiang Gao, Zhong Su   +3 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Gut Microbiome Functional Reprogramming Reflects Divergent Social Strategies in a Wild Primate

Integrative Zoology, EarlyView.
Wild golden snub‐nosed monkeys employ divergent social strategies, forming reproductive one‐male units and bachelor all‐male units. We reveal that these social structures, intertwined with seasonal diets, drive distinct functional reprogramming in their gut microbiomes. This adaptive microbial plasticity plays a crucial role in primate socio‐ecological
Guanwei Lan, Xianjun Li, Zhantao Lu, Yue Zhang, Feifei Feng, Juan Liu, Wei Wu, Jiabin Liu, Yanshan Zhou, Jiang Gu, Rui Ma, Dunwu Qi   +11 more
wiley   +1 more source

Effects of ractopamine hcl (paylean) and α-lipoic acid on the growth performance and carcass characteristics of finishing pigs [PDF]

, 2008
A total of 48 gilts (initially 211 lb) were used to evaluate the effects of ractopamine HCl and α-lipoic acid on finishing pig performance and carcass characteristics. Pigs were blocked by weight and randomly allotted to 1 of 4 dietary treatments in a 22-
J R Bergstrom, R C Sulabo, Gipe, A N, Goodband, Robert D., J A Gunderson, Michael D Tokach, Gunderson, J.A., DeRouchey, Joel M, Houser, Terry A, Nelssen, Jim L, Dritz, Steven S, Nelssen, Jim L., Jacela, J., Dritz, Steven S., Jim L Nelssen, Sulabo, R.C., Sulabo, R C, Terry A Houser, J M Benz, Joel M DeRouchey, Bergstrom, J R, Goodband, Robert D, Tokach, Michael D., Gipe, A.N., Tokach, Michael D, Benz, J M, Robert D Goodband, Benz, J.M., Steven S Dritz, Bergstrom, J.R., J Jacela, Jacela, J, Houser, Terry A., DeRouchey, Joel M., Gunderson, J A, A N Gipe   +35 more
core   +1 more source