Results 91 to 100 of about 34,912 (203)
Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell +14 more
wiley +1 more source
Journal of Associated Medical Sciences, 2009 α-thalassemia is characterized by quantitive abnormality of α-globin chain commonly occur in Thailand. Heterozygote of α-thalassemia is clinically asymtomatic, but with modest alteration of hematologic parameters.
Tiemjan Kewkarnkha +2 more
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American Journal of Hematology, Volume 101, Issue 4, Page 718-727, April 2026.ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt +9 more
wiley +1 more source
Red blood cell indices and\ud Prevalence of Hemoglobinopathies and Glucose 6 Phosphate Dehydrogenase Deficiencies in Male Tanzanian Residents of Dar es Salaam [PDF]
Hemoglobinopathies, disorders of hemoglobin structure and production, are one of the most common monogenic disorders in humans. Glucose 6 phosphate dehydrogenase deficiency (G6PD) is an inherited enzymopathy resulting in increased oxygen stress ...
Athuman, Thabit +14 more
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American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque +2 more
wiley +1 more source
Genetics and Genomics in Sickle Cell Disease in Africa
American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya +2 more
wiley +1 more source
Frontiers in HematologyBackgroundThalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications.
Kunapa Iam-arunthai +5 more
doaj +1 more source
The research of the detection of thalassaemia multiple mutations by next-generation sequencing technology [PDF]
, 2015 地中海贫血又称珠蛋白生成障碍性贫血，早期的病例来自地中海地区，故称为地中海贫血，是世界范围内影响最大的单基因病之一，遵循孟德尔遗传定律。该病是由珠蛋白基因的缺失或点突变所致，根据其变异的肽链可分为α地贫和β地贫。由于其基因缺陷的复杂、多样，使缺乏的珠蛋白链类型、数量、临床症状变异较大。临床上对中、重度地中海贫血无行之有效的治疗方法，给社会、家庭、个人带来了沉重的经济及精神负担。故有效检出地中海贫血患者、进行婚前孕前指导、产前诊断、避免地中海贫血患儿的出生，有着极其重要的社会意义 ...
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