Results 31 to 40 of about 34,320 (185)

Analysis of a1 and a2 globin genes among patients with hemoglobin Adana in Malaysia [PDF]

, 2016
Hemoglobin (Hb) Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a non-deletional α-thalassemia variant found in Malaysia. An improvement in the molecular techniques in recent years has made identification of Hb Adana much easier.
George, E., Hussein, N. H., Ismail, P., Lai, M. I., Lee, T. Y., Othman, R., Ramachandran, V., Tan, J. A. M. A., Teh, L. K.   +8 more
core   +1 more source

Sensitivitas dan Spesifisitas α-Globin Strip Assay dalam Mendeteksi Mutasi Thalassemia-α

Sari Pediatri, 2016
Latar belakang. Thalassemia-α merupakan kelainan genetik yang dapat menyebabkan gejala klinis berat pada pasien. Deteksi mutasi thalassemia-α di Indonesia umumnya menggunakan metode PCR sebagai baku emas.
Dian Puspita Sari, Pustika Amalia Wahidiyat   +1 more
doaj   +1 more source

Prevalence and Genetic Analysis of Thalassemia and Hemoglobinopathy in Different Ethnic Groups and Regions in Hainan Island, Southeast China

Frontiers in Genetics, 2022
Background: There are limited studies on the molecular profile of thalassemia in Hainan, the free trade island in China. Our aim was to reveal the prevalence and molecular mutation spectrum of thalassemia in different ethnic groups and regions of Hainan ...
Min Wang, Min Wang, Xiaozhuang Zhang, Xiaozhuang Zhang, Yubin Zhang, Yubin Zhang, Meifang Xiao, Meifang Xiao   +7 more
doaj   +1 more source

Alpha thalassemia and alpha-MRE haplotypes in Uruguayan patients with microcytosis and hypochromia without anemia [PDF]

Genetics and Molecular Biology, 2021
Alpha thalassemia is the most common genetic disorder across the world, being the α-3.7 deletion the most frequent mutation. In order to analyze the spectrum and origin of alpha thalassemia mutations in Uruguay, we obtained a sample of 168 unrelated ...
Ana María Soler, Bruna Facanali Piellusch, Lorena da Silveira, Gisele Audrei Pedroso, Pablo López, Enrique Savio, María de Fatima Sonati, Julio da Luz   +7 more
doaj   +1 more source

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania [PDF]

, 2015
Populations exposed to Plasmodium falciparum infection develop genetic mechanisms of protection against severe malarial disease. Despite decades of genetic epidemiological research, the sickle cell trait (HbAS) sickle cell polymorphism, ABO blood group ...
,, Clark, Taane G., Drakeley, Christopher J., Manjurano, Alphaxard, Maxwell, Caroline, Mtove, George, Nadjm, Behzad, Olomi, Raimos, Reyburn, Hugh, Riley, Eleanor M., Sepulveda, Nuno, Wangai, Hannah   +11 more
core   +4 more sources

Study of discriminant factor M/H ratio in screening for β thalassemia trait

IP Journal of Diagnostic Pathology and Oncology, 2020
Introduction: Beta Thalassemia syndrome is a group of hereditary disorders characterized by genetic deficiency in the synthesis of beta globin chains located on chromosome 11. A major diagnostic challenge is to differentiate between mild microcytic hypochromic anaemia due to BTT from other causes such as iron deficiency (IDA), sideroblastic anaemia etc.
openaire   +2 more sources

High prevalence of thalassemia in migrant populations in Guangdong Province, China [PDF]

, 2014
BACKGROUND: The objectives of this study were to estimate the prevalence of thalassemia and to analyze the need for public health services for migrant populations in different cities in Guangdong Province, China.
Ai-hua Yin, Bing Li, Li Wu, Ming-yong Luo, Qing-guo Zhao, Shou-yi Yu, Xiao-zhuang Zhang, Yuan-zhu Ma   +7 more
core   +1 more source

The hypercoagulation state among major β-thalassemia patients at H. Adam Malik Hospital, Medan, Indonesia

Bali Medical Journal, 2019
Background: Thalassemia is the most common hereditary blood disorder in the world and Indonesia. Major β-thalassemia is classified as Transfusion-Dependent Thalassemia (TDT). Specific changes in the composition of red cell membrane lipids and hemosiderosis may lead to hypercoagulation.
Jane Tetraulina Silitonga, Adi Koesoema Aman, Bidasari Lubis   +2 more
openaire   +1 more source

Prevalence of B-Thalassemia Carriers Among a Cohort of University Students in Hawler Province of Iraqi Kurdistan

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 2017
         A representative sample of a thousand volunteer university students was screened for evidence of thalassemia minor.Complete blood counts using automated blood cell analysers and blood smears were examined. Patients having anemia, abnormal red cell indices or morphological features of thalassemia minor like hypochromia, microcytosis, target ...
Abdulkadir A. Alnakshabandi, Huda A. Muhammad   +1 more
openaire   +3 more sources

The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease [PDF]

, 2006
Sickle cell disease (SCD) is one of the most common inherited diseases in the world and the patients present notorious clinical heterogeneity. It is known that patients with SCD present activation of the blood coagulation and fibrinolytic systems ...
Beltrão, A.c.s., Figueiredo, Maria Stella, Gil, I.c.p., Lourenco, Dayse Maria, Moreira Neto, F., Morelli, V.m., Noguti, Maria Aparecida Eiko   +6 more
core   +3 more sources