α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li +6 more
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Biophysical characterization of lynx‐nicotinic receptor interactions using atomic force microscopy
FASEB BioAdvances, 2021 Nicotinic acetylcholine receptors (nAChRs) are broadly expressed in the central and peripheral nervous systems, playing essential roles in cholinergic neurotransmission. The lynx family proteins, a subset of the Ly6/uPAR superfamily expressed in multiple
Avani V. Pisapati +8 more
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Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]
Eur J NeurosciABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
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Nicotinic Acetylcholine Receptors in the Respiratory Tract [PDF]
Molecules, 2021 Nicotinic acetylcholine receptors (nAChR) are widely distributed in neuronal and non-neuronal tissues, where they play diverse physiological roles. In this review, we highlight the recent findings regarding the role of nAChR in the respiratory tract with
Monika I. Hollenhorst +1 more
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Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. [PDF]
PLoS ONE, 2015 Nicotine elicits bitter taste by activating TRPM5-dependent and TRPM5-independent but neuronal nAChR-dependent pathways. The nAChRs represent common targets at which acetylcholine, nicotine and ethanol functionally interact in the central nervous system.
Zuo Jun Ren +5 more
doaj +7 more sources
Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors [PDF]
British Journal of Pharmacology, Volume 177, Issue 24, Page 5595-5608, December 2020., 2020 Background and Purpose Mucociliary clearance is an innate immune process of the airways, essential for removal of respiratory pathogens. It depends on ciliary beat and ion and fluid homeostasis of the epithelium.
Fronius, Martin +4 more
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Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Azadi MH +3 more
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Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Magnussen JH.
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An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs. [PDF]
FASEB Jα‐RoIA is an atypical N‐terminally elongated conotoxin discovered in Conus rolani. N‐terminal elongation delays activity in vivo; however, this elongation must be removed to block muscle nicotinic acetylcholine receptors (nAChRs). Only the truncated ribbon isoform of RoIA blocks muscle nAChRs.
Giglio ML +9 more
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Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments. [PDF]
CNS Neurosci TherChanges of neuronal nAChRs in various cognitive impairments. The function of nAChRs is related to learning and memory and anti‐neurotoxicity. The modifications of nAChRs have their characteristics in different cognitive impairments. A variety of nAChR agonists and inhibitors have been and are being tested for treatment of cognitive impairment ...
Guan ZZ.
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