Results 41 to 50 of about 2,175 (165)
RIC-3 expression and splicing regulate nAChR functional expression [PDF]
, 2016 Effects of FL human RIC-3 vs. mouse FL on Îą7 nAChR functional expression in X. leavis oocytes. Results were normalized to currents recorded in oocytes expressing the respective receptors in the absence of RIC-3 in the same experiment.
Emiliano Cohen +6 more
core +2 more sources
Degradation kinetics of α‐conotoxin TxID
FEBS Open Bio, 2019 α‐Conotoxin (CTx) TxID is a potent α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that has been suggested as a potential drug candidate to treat addiction and small cell lung cancer.
Pan Xu +6 more
doaj +1 more source
Nicotinic receptor modulation to treat alcohol and drug dependence [PDF]
, 2015 Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant.
Bell, Richard L. +2 more
core +2 more sources
TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors
Frontiers in Pharmacology, 2017 (E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I ...
Teagan R. Wall +12 more
doaj +1 more source
SLAS Discovery, 2022 There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicotine,
Michelle Kassner +6 more
doaj +1 more source
Pyrrolidinyl benzofurans and benzodioxanes: Selective α4β2 nicotinic acetylcholine receptor ligands with different activity profiles at the two receptor stoichiometries [PDF]
, 2022 A series of racemic benzofurans bearing N-methyl-2-pyrrolidinyl residue at C(2) or C(3) has been synthesized and tested for affinity at the α4β2 and α3β4 nicotine acetylcholine receptors (nAChRs).
A. K. Hamouda +3 more
core +1 more source
Molecular Regulation of Betulinic Acid on α3β4 Nicotinic Acetylcholine Receptors
Molecules, 2021 Betulinic acid (BA) is a major constituent of Zizyphus seeds that have been long used as therapeutic agents for sleep-related issues in Asia. BA is a pentacyclic triterpenoid. It also possesses various anti-cancer and anti-inflammatory effects.
Shinhui Lee +5 more
doaj +1 more source
Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors [PDF]
, 2015 Regulation of the ‘neuronal’ nicotinic acetylcholine receptors (nAChRs) is implicated in both tobacco addiction and smoking-dependent tumor promotion.
Andrea Becchetti +3 more
core +2 more sources
Inside-out neuropharmacology of nicotinic drugs [PDF]
, 2015 Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of chronic exposure to nicotine; but it is one of several consequences of pharmacological chaperoning by nicotine and by some other nicotinic ligands, especially ...
Henderson, Brandon J., Lester, Henry A.
core +1 more source
PLoS ONE, 2011 Acetylcholine-based neurotransmission is regulated by cationic, ligand-gated ion channels called nicotinic acetylcholine receptors (nAChRs). These receptors have been linked to numerous neurological diseases and disorders such as Alzheimer's disease ...
Ryan E Pavlovicz +5 more
doaj +1 more source