Results 81 to 90 of about 2,175 (165)

DSPE-PEG Modification of α-Conotoxin TxID

Marine Drugs, 2019
In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time. The reaction
Weinan Zhao, Yang Xiong, Dongting Zhangsun, Sulan Luo   +3 more
doaj   +1 more source

Computational Design of α‐Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes

Chemistry – A European Journal, Volume 30, Issue 7, February 1, 2024.
FoldX was benchmarked as the best energy prediction method, and seven accurate molecular models of α‐conotoxin/nAChRs were developed as surrogates for the experimental complexes. The combined use of FoldX and these molecular models emerged as an effective approach to predict α‐conotoxins with improved pharmaceutical properties.
Xiaosa Wu, Arik J. Hone, Yen‐Hua Huang, Richard J. Clark, J. Michael McIntosh, Quentin Kaas, David J. Craik   +6 more
wiley   +1 more source

Synthesis of Allosteric Modulators for Nicotinic Acetylcholine Receptors [PDF]

, 2012
College of Arts and Sciences Undergraduate Research ScholarshipNicotinic acetylcholine receptors (nAChR) can be found throughout the human nervous system. The receptors regulate a multitude of functions, including development, inflammation, and movement.
Young, Jason
core  

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB Journal, Volume 38, Issue 1, 15 January 2024.
Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J. Michael McIntosh, Paul Whiteaker   +12 more
wiley   +1 more source

Nicotinic acetylcholine receptors mediate lung cancer growth

Frontiers in Physiology, 2013
Ion channels modulate ion flux across cell membranes, activate signal transduction pathways, and influence cellular transport – vital biological functions that are inexorably linked to cellular processes that go awry during carcinogenesis.
Ma. Reina eImprogo, Lindsey G Soll, Andrew R Tapper, Paul D Gardner   +3 more
doaj   +1 more source

Recent Developments In Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors [PDF]

, 2014
Nicotinic acetylcholine receptors (nAChRs) have been investigated for developing drugs that can potentially treat various central nervous system disorders.
Caldarone, Barbara J., Eaton, J. Brek, Kozikowski, Alan P., Lukas, Ronald J., Yu, Li Fang, Zhang, Han Kun   +5 more
core   +3 more sources

Identification Of Novel α4β2-Nicotinic Acetylcholine Receptor (Nachr) Agonists Based On An Isoxazole Ether Scaffold That Demonstrate Antidepressant-Like Activity [PDF]

, 2012
There is considerable evidence to support the hypothesis that the blockade of nAChR is responsible for the antidepressant action of nicotinic ligands.
Brunner, Dani, Caldarone, Barbara, Eaton, J. Brek, Fedolak, Allison, Hanania, Taleen, Kozikowski, Alan P., Lukas, Ronald J., Tuckmantel, Werner, Yu, Li Fang   +8 more
core   +2 more sources

Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors.
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe   +7 more
doaj   +1 more source

Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor

Marine Drugs, 2018
α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype.
Jie Ren, Rui Li, Jiong Ning, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +6 more
doaj   +1 more source

Cigarette Smoke (CS) and Nicotine Delay Neutrophil Spontaneous Death via Suppressing Production of Diphosphoinositol Pentakisphosphate [PDF]

, 2014
Diphosphoinositol pentakisphosphate (InsP7), a higher inositol phosphate containing energetic pyrophosphate bonds, is beginning to emerge as a key cellular signaling molecule.
Bajrami, Besnik, Cao, Shannan, Kwak, Hyunjeong, Li, Hongmei, Liu, Peng, Luo, Hongbo, Xu, Yuanfu, Ye, Keqiang, Zhou, Jiaxi, Zhou, Yuan, Zhu, Haiyan   +10 more
core   +1 more source