Results 71 to 80 of about 10,488 (180)

Relationship Between Gut Microbiota and Cancer Neuro‐Immunity

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Tumour cells influence neural activity and microbiota homeostasis through cytokines and immune modulation. Meanwhile, gut microbiota regulates neural function through metabolic products, affects immune responses via neurotransmitters, feedback regulates neural activity and influences tumour microenvironment.
Danyang Wang, Ruirui Cui, Chang You, Wanlin Zheng, Luyao Wang, Yingqi Yang, Hongkai Yu, Bota Cui   +7 more
wiley   +1 more source

Nicotinic receptor components of amyloid beta 42 proteome regulation in human neural cells.

PLoS ONE, 2022
Alzheimer's disease (AD) is associated with chronic neurodegeneration often accompanied by elevated levels of the neurotoxic peptide amyloid-beta 1-42 (Aβ42) in the brain.
Patricia Sinclair, Nadine Kabbani
doaj   +1 more source

Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers [PDF]

, 2017
Cigarette smoking is associated with increased risk for all histologic types of lung cancer, but why the strength of this association is stronger for squamous cell carcinoma than adenocarcinoma of the lung (SQC-L, ADC-L) is not fully understood ...
Arnalich, Francisco, Atienza, Gema, Bordas, Anna, Castro, Javier de, Cedillo, José Luis, Esteban-Rodríguez, Isabel, Fernández-Capitan, Carmen, Guerra-Pastrián, Laura, Martín-Sánchez, Carolina, Montiel, Carmen, Ríos, Juan José   +10 more
core   +3 more sources

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

Addiction, Volume 121, Issue 3, Page 499-509, March 2026.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou, Zhenxiao Huang, Qingqing Song, Xin Xia, Anqi Cheng, Zhao Liu, Min Wang, Tingfen Ji, Ailifeire Aihemaiti, Ying Xie, Yi Liu, Yuxin Shi, Shunyi Shi, Yingman Gao, Hang Liu, Jiahui He, Liang Zhao, Dan Xiao, Chen Wang   +18 more
wiley   +1 more source

Expression of the α7 nicotinic acetylcholine receptor in human lung cells [PDF]

, 2005
Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor.
O Delbono, MG Cattaneo, A Codignola, HM Schuller, HM Schuller, HK Plummer III, BJ Sheppard, P Tarroni, HM Schuller, BA Jull, DE Johnson, HM Schuller, HK Plummer III, X Peng, DL Carlisle, S Couturier, J Lindstrom, P Song, P Song, HM Schuller, L Ke, M Bencherif, S Wonnacott, HS Sekhorn   +23 more
core   +2 more sources

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, Volume 67, Issue 3, Page 1449-1468, March 2026.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +1 more source

Nicotine deteriorates the osteogenic differentiation of periodontal ligament stem cells through α7 nicotinic acetylcholine receptor regulating Wnt pathway. [PDF]

PLoS ONE, 2013
AIMS: Cigarette smoking is one of the high risk factors of adult chronic periodontitis and nicotine is the well established toxic substance in cigarette. However, the mechanism of nicotine induced periodontitis is still unknown.
Zhifei Zhou, Bei Li, Zhiwei Dong, Fen Liu, Yu Zhang, Yang Yu, Fengqing Shang, Lizheng Wu, Xiaojing Wang, Yan Jin   +9 more
doaj   +1 more source

Cholinergic Enhancement of Cell Proliferation in the Postnatal Neurogenic Niche of the Mammalian Spinal Cord [PDF]

, 2015
The region surrounding the central canal (CC) of the spinal cord is a highly plastic area, defined as a postnatal neurogenic niche. Within this region are ependymal cells which can proliferate and differentiate to form new astrocytes and oligodendrocytes
Andrews, Barber, Barnabe-Heider, Berg, Campbell, Cooper-Kuhn, Corns, Danilov, Decimo, Foret, Frolich, Garzon, Graham, Harvey, Harvey, Huang, Hugnot, Johansson, Kaneko, Kotani, Lacar, Larocque, Marichal, Meletis, Menezes, Mothe, Paez-Gonzalez, Petruska, Pfenninger, Phelps, Reimer, Rogers, Seguela, Sofroniew, Stoeckel, Tohgi, Turnley, Velez-Fort, Vigh, Wada, Weissman, Wonnacott, Wu, Zagoraiou   +43 more
core   +2 more sources

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source