Results 101 to 110 of about 3,518 (150)

Image_1_Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis.TIFF

, 2019
Sepsis is one of the leading causes of death in hospitalized patients and the chronic and low-grade inflammation observed in obesity seems to worsen susceptibility and morbidity of infections.
Leticia Foglia Santucci (6496106), Anelise Cristina Parras Souza (6496094), Camila Libardi Amaral (6496100), Simone Ferreira Lemes (6496103), Camilla Mendes Souza (6496097), Marciane Milanski (571280), Adriana Souza Torsoni (2901056), Marcio Alberto Torsoni (6496109)   +7 more
core   +1 more source

Sinomenine regulates the AKT/FOXO3/GLUL pathway to inhibit pulmonary fibroblast-to-myofibroblast transition via α7nAChR against rheumatoid arthritis associated interstitial lung disease

Pharmacological Research
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation with limited treatment options. Identifying anti-arthritic agents that concurrently protect against ILD is clinically significant.
Muqiu Liu, Huaizhi Du, Junhui Zheng, Min Liu, Zhihao Jiang, Jieying Huang, Sihe Jiang, Lang Yi, Lingyu Zhang, Yanwu Li, Qun Du, Liang Liu, Haojie Ni, Xiaojun Zhang, Hua Zhou, Yan Dong   +15 more
doaj   +1 more source

α7nAChR mediates the protective effect and autophagy of ANI/NEO combination on DSS-induced colitis in mice.

WT and α7nAChR KO mice were received 3% DSS for 7 days and the DSS mice were treated with vehicle or ANI/NEO compound (20 mg/kg and 40 μg/kg, i.p.) twice a day from day 3 to day 7. (A) The body weight loss was tested in the mice. n = 4 per group. #P (TIF)
Danni Zhu (14781238), Ni Kong (17965526), Ting Han (170267), Guangyu Zhang (146127), Qin Xu (93193), Chong Liu (450204), Mengzhen Liu (5523035), Zhiwei Dong (500616), Hui Yan (117134), Jingjing Zhang (163589), Ping Ke (3110763)   +10 more
core   +1 more source

Blockade of the α7nAChR abolishes DEX-induced short-term cardioprotection against I/R.

, 2019
Rats were subjected to intraperitoneal injection of saline or methyllycaconitine (MLA, α7nAChR antagonist) before DEX treatment. (a-b) Infarct sizes determined by Evans blue/TTC staining and representative images of each group are shown.
Juan Zhang (48597), Ke Peng (2220973), Huayue Liu (7041752), Fan Xia (219575), Haifeng Zhao (607312), Xiaowen Meng (7041755), Chen Chen (6544), Fuhai Ji (469046)   +7 more
core   +1 more source

Paradoxical Regulation of α7nAChR and NLRP3 Inflammasome in Gastrointestinal Cancers and Ulcerative Colitis

Metabolites
Background: Gastrointestinal (GI) cancers are common and pose a major public health issue. An inflammatory microenvironment drives their development and progression.
Gulten Ates, Ilker Ozgur, Ismail Cem Sormaz   +2 more
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GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function

, 2020
Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside
Sana DOUAOUI (8779967), Merzak GHERNAOUT (8779976), Reda DJIDJIK (8779970), Fawzi DERRAR (8779985), Chafia TOUIL-BOUKOFFA (8779979), Mustapha OUMOUNA (8779982), Yassine Amrani (188117), Mokhtar BOUBAKEUR (8779973)   +7 more
core  

Do MLA Reversal Experiments Establish α7nAChR-Dependent Neuroprotection by Remimazolam After TBI? [Letter]. [PDF]

Drug Des Devel Ther
Zhang S, Li T, Liu Y.
europepmc   +1 more source

Remimazolam Attenuates Neurological Injury After TBI: A Potential Role of α7nAChR-Associated Mitophagy Enhancement and Pyroptosis Suppression in BV2 Cells. [PDF]

Drug Des Devel Ther
Li L, Bao R, Meng Y, Li X, Li H, Duan P, Bi Y, Chen J, Xing Y, Luo L, Yu Y, Yu M, Cui M, Zhang B.   +13 more
europepmc   +1 more source

Common metabolic, environmental, and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders. [PDF]

Front Neurol
Vallés AS, Barrantes FJ.
europepmc   +1 more source

α７ｎＡＣｈＲ激动剂对血管紧张素Ⅱ诱导的心肌成纤维细胞增殖和胶原合成的影响及其分子机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要： 【目的】 探讨α７烟碱乙酰胆碱受体（α７ ｎＡｃｈＲ）激动剂对血管紧张素Ⅱ（ＡｎｇⅡ）诱导的心肌成纤维细胞增殖和胶原合成的影响及其分子机制。【方法】 培养出生２～３ｄ大鼠心肌成纤维细胞（ＣＦ），取传代２ ～ ４代细胞，分为①空白对照组（ｃｏｎｔｒｏｌ）；②模型组（ＡｎｇⅡ１０－７ ｍｏｌ／Ｌ）；③ＡＣｈ预处理组：ＡＣｈ ＋ ＡｎｇⅡ组（ＡＣｈ １０－４ ｍｏｌ／Ｌ ＋ ＡｎｇⅡ１０－７ ｍｏｌ／Ｌ）；④α７ｎＡＣｈＲ激动剂组：α７ｎＡＣｈＲ激动剂＋ ＡｎｇⅡ组（ＰＮＵ－２８２９８７ ５ ...
doaj