Results 81 to 90 of about 3,518 (150)

The Role of α7nAChR in Alzheimer’s Disease

Shengwu huaxue yu shengwu wuli jinzhan
As the global population continues to age, the incidence of Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, continues to rise significantly.
DING Dao-Bo, MU Wen-Jun, LI Xin, CHEN Huan, HOU Hong-Wei, HU Qing-Yuan   +5 more
doaj   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, Volume 38, Issue 5, May 2026.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

Molecular Medicine, 2019
Background Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition of high-mobility group box 1 ...
Tao Jiang, Meiyan Wu, Zhanqin Zhang, Chaoying Yan, Zhi Ma, Shan He, Wei Yuan, Kairui Pu, Qiang Wang   +8 more
doaj   +1 more source

Transcutaneous auricular vagus nerve stimulation promotes recovery from otitis media by activating the α7nAChR-mediated anti-inflammatory pathway. [PDF]

Inflamm Regen
Background Otitis media (OM) is an inflammatory disease of the middle ear characterized by mucosal remodeling, effusion, and conductive hearing loss. Although antibiotics and surgical procedures remain standard treatments, their efficacy is often limited
Shin N, Park S, Suh MW, Lee SY, Lee JH, Park MK.   +5 more
europepmc   +2 more sources

Blockade of the α7nAChR abolishes DEX-induced long-term cardioprotection against I/R.

, 2019
To investigate whether the α7nAChR was involved in the long-term cardioprotective effects of DEX, we administrate MLA, the selective antagonist of α7nAChR, prior to DEX treatment followed with I/R operation.
Juan Zhang (48597), Ke Peng (2220973), Huayue Liu (7041752), Fan Xia (219575), Haifeng Zhao (607312), Xiaowen Meng (7041755), Chen Chen (6544), Fuhai Ji (469046)   +7 more
core   +1 more source

Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis [PDF]

, 2019
Sepsis is one of the leading causes of death in hospitalized patients and the chronic and low-grade inflammation observed in obesity seems to worsen susceptibility and morbidity of infections.
Leticia Foglia Santucci, Anelise Cristina Parras Souza, Simone Ferreira Lemes, Camilla Mendes Souza, Marcio Alberto Torsoni, Camila Libardi Amaral, Marciane Milanski, Adriana Souza Torsoni   +7 more
core   +1 more source

Deciphering the concentration-dependent modulation effect of CT16 on the human α7 nicotinic receptor: Insights from molecular dynamics simulation

ChemPhysMater
Alzheimer's disease (AD) is closely linked to the accumulation of amyloid-beta peptides (Aβ), which impair synaptic plasticity and contribute to cognitive decline.
Chuanbo Wang, Jinfei Mei, Mengke Jia, Sajjad Ahmad, Zijian Liu, Hongqi Ai   +5 more
doaj   +1 more source

Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation

Journal of Neuroinflammation
Background The involvement of the autonomic nervous system in the regulation of inflammation is an emerging concept with significant potential for clinical applications.
Kasey R. Keever, Kui Cui, Jared L. Casteel, Sanjay Singh, Donald B. Hoover, David L. Williams, Valentin A. Pavlov, Valentin P. Yakubenko   +7 more
doaj   +1 more source

Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats

Journal of Neuroinflammation, 2012
Background We have previously reported that electroacupuncture (EA) pretreatment induced tolerance against cerebral ischemic injury, but the mechanisms underlying this effect of EA are unknown.
Wang Qiang, Wang Feng, Li Xin, Yang Qianzi, Li Xuying, Xu Ning, Huang Yi, Zhang Qiaomei, Gou Xingchun, Chen Shaoyang, Xiong Lize   +10 more
doaj   +1 more source