Results 21 to 30 of about 19,422 (160)

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D₂ Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules, 2023
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley   +12 more
doaj   +1 more source

High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction via Inhibition of β-Arrestin-Signaling

Frontiers in Physiology, 2021
An increased vulnerability has been detected after ischemia/reperfusion injury in cardiomyocytes in diabetic patients. Glucagon-like peptide-1 (GLP-1) has been proven to have a notable cardioprotective effect in cardiomyocytes.
Xietian Pan, Chengxiang Li, Haokao Gao
doaj   +1 more source

β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation

Frontiers in Endocrinology, 2020
Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional ...
Bastian Czogalla, Alexandra Partenheimer, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt, Doris Mayr, Sven Mahner, Alexander Burges, Manuela Simoni, Manuela Simoni, Manuela Simoni, Manuela Simoni, Beatrice Melli, Riccardo Benevelli, Sara Bertini, Livio Casarini, Livio Casarini, Fabian Trillsch   +17 more
doaj   +1 more source

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences, 2012
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj   +1 more source

Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells. [PDF]

PLoS ONE, 2012
Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important for their desensitization.
Kshitij Gupta, Hariharan Subramanian, Andreas Klos, Hydar Ali   +3 more
doaj   +1 more source

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

Cell Reports, 2013
G-protein-coupled receptors (GPCRs) are typically present in a basal, inactive state but, when bound to an agonist, activate downstream signaling cascades. In studying arrestin regulation of opioid receptors in dorsal root ganglia (DRG) neurons, we find that agonists of delta opioid receptors (δORs) activate cofilin through Rho-associated coiled-coil ...
Mittal, N, Roberts, K, Pal, K, Bentolila, LA, Fultz, E, Minasyan, A, Cahill, C, Pradhan, A, Conner, D, DeFea, K, Evans, C, Walwyn, W   +11 more
openaire   +6 more sources

Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2011
The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali   +4 more
doaj   +1 more source

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]

PLoS ONE, 2015
In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde, Ryan T Strachan, Julia K L Walker   +2 more
doaj   +1 more source

β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]

PLoS ONE, 2014
β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz, Verena Dürsch, Jakub Harnoš, Vitezslav Bryja, Marc Gentzel, Alexandra Schambony   +5 more
doaj   +1 more source

β-Arrestin-dependent deactivation of mouse melanopsin.

PLoS ONE, 2014
In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj   +1 more source