Results 131 to 140 of about 1,643,257 (174)

Discovery of β-carboline-(phenylsulfonyl)furoxan hybrids as potential anti-breast cancer agents.

Bioorganic & Medicinal Chemistry Letters, 2021
The cytotoxicity properties of the β-carboline alkaloids have been broadly investigated. However, the potential application of β-carbolines was hindered due to the moderate activity in cancer.
Xu Hu, Xiang Gao, Gang Gao, Yanbing Wang, Hao Cao, Dahong Li, H. Hua   +6 more
semanticscholar   +1 more source

Application of Pictet–Spengler Reaction to Indole-Based Alkaloids Containing Tetrahydro-β-carboline Scaffold in Combinatorial Chemistry

ACS Combinatorial Science, 2017
Barnali Maiti, Kaushik Chanda, R Nishanth Rao   +2 more
exaly   +2 more sources

Metal complexes of β-carboline: Advances in anticancer therapeutics

, 2021
The platinum-based complexes were the first anticancer metallotherapeutics to emerge and since their discovery several other coordination compounds consisting of transition metal ions of variable oxidation states in complex with various ligands have been
Y. Ayipo, W. Osunniran, M. Mordi
semanticscholar   +1 more source

Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives

Journal of Molecular Structure, 2021
A new series of benzimidazole/benzoxazole linked β-carbolines (9a-j) were rationally designed and synthesized by combining two different anti-cancer fragments.
R. Sireesha, R. Sreenivasulu, Choragudi Chandrasekhar, S. S. Jadav, Y. Pavani, M. Rao, M. Subbarao   +6 more
semanticscholar   +1 more source

Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.

Food Chemistry, 2020
The simultaneous formation of acrylamide; β-carboline heterocyclic amines (HAs): harmane and norharmane; and advanced glycation end products (AGEs) (Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL)) was analyzed based on an aqueous model ...
Wei Quan, Yong Li, Ye Jiao, Chaoyi Xue, Guoping Liu, Zhaojun Wang, Zhiyong He, Fang Qin, Maomao Zeng, Jie Chen   +9 more
semanticscholar   +1 more source

Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer.

Chemico-Biological Interactions, 2020
Cell cycle dysregulation is the mainstay of aberrant cell proliferation, which leads to tumor progression. Mutations in tumor cells initiate various dysregulated pathways and spontaneous over-proliferation with genomic/chromosomal instability.
Imad Ahmad, S. Fakhri, H. Khan, P. Jeandet, M. Aschner, Zhi-Ling Yu   +5 more
semanticscholar   +1 more source

β-Carboline Alkaloids from the Seeds of Peganum harmala and Their Anti-HSV-2 Virus Activities.

Organic Letters, 2020
Pegaharines A-G (1-6), six novel β-carboline alkaloids representing three types of skeleton, were isolated from the seeds of Peganum harmala. Compound 1 is a peculiar β-carboline alkaloid characterized by the unprecedented carbon skeleton of an azepine ...
Zhongnan Wu, Neng-hua Chen, Qing Tang, Si Chen, Zhaochun Zhan, Yu-bo Zhang, Guocai Wang, Yao-lan Li, W. Ye   +8 more
semanticscholar   +1 more source

Resource distribution, pharmacological activity, toxicology and clinical drugs of β-Carboline alkaloids: An updated and systematic review.

Fitoterapia
β-Carboline alkaloids are a broad class of indole alkaloids that were first isolated from Peganum harmala L., a traditional Chinese herbal remedy. β-Carboline alkaloids have been found to have many pharmacological activities, including anti-inflammatory,
Lili Yu, N. Shen, Jiani Ren, Huawei Xin, Yulei Cui   +4 more
semanticscholar   +1 more source

The Progress in Pictet‐Spengler β‐Carboline Synthesis under Green Conditions

ChemistrySelect
β‐Carboline ring is widely distributed in nature and several β‐carboline alkaloids were extracted from marine creatures, bacteria, fungi, food stuffs, plants, and mammals.
Mohamed O. Mousa, M. E. Adly, Amr M. Mahmoud, H. B. El‐Nassan   +3 more
semanticscholar   +1 more source

Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia.

Journal of Natural Products, 2020
Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 ...
Guy Kleks, Sandra Duffy, L. Lucantoni, V. Avery, A. Carroll   +4 more
semanticscholar   +1 more source