Results 141 to 150 of about 1,643,257 (174)

Pegaharmols A-B, Axially Chiral β-Carboline-quinazoline Dimers from the Roots of Peganum harmala.

Organic Letters, 2020
Two nonbiaryl axially chiral β-carboline-quinazoline dimers, pegaharmols A (1) and B (2), were isolated from the roots of Peganum harmala. Their planar structures were elucidated by the spectroscopic methods of high-resolution mass spectrometry and 1D ...
Shengge Li, Yuetong Wang, Qin Zhang, Kai-Bo Wang, Jingjing Xue, Dahong Li, Yong-kui Jing, B. Lin, H. Hua   +8 more
semanticscholar   +1 more source

Discovery of β-Carboline Oxadiazole Derivatives as Fungicidal Agents against Rice Sheath Blight.

Journal of Agricultural and Food Chemistry, 2018
A series of β-carboline oxadiazoles were synthesized, and their fungicidal activities and mechanism of action against rice sheath blight caused by Rhizoctonia solani was evaluated.
Zhi‐Jun Zhang, Zhi-Yan Jiang, Qi Zhu, G. Zhong   +3 more
semanticscholar   +1 more source

β-Carboline and N-hydroxycinnamamide hybrids as anticancer agents for drug-resistant hepatocellular carcinoma.

European journal of medicinal chemistry, 2019
In an effort to develop anticancer agents that may overcome drug resistance, the number one reason in caner death, we have developed a series of novel hybrids of β-carboline and N-hydroxycinnamamide as histone deacetylase (HDAC) inhibitors.
Yong Ling, Weijie Gao, Changchun Ling, Ji Liu, Chi Meng, Jianqiang Qian, Siqun Liu, Hui Gan, Hongmei Wu, Jinhua Tao, H. Dai, Yanan Zhang   +11 more
semanticscholar   +1 more source

Recent update on the anti-infective potential of β-carboline analogs.

Mini-Reviews in Medical Chemistry, 2020
β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial ...
Faheem, B. K. Kumar, K. Sekhar, Selvaraj Kunjiappan, J. Jamalis, R. Balaña-Fouce, Murugesan Sankaranarayanan   +6 more
semanticscholar   +1 more source

A Natural Alkaloid, β-Carboline, as a One- and Two-Photon Responsive Fluorescent Photoremovable Protecting Group: Sequential Release of the Same or Different Carboxylic Acids.

Organic Letters, 2020
The β-carboline moiety, substituted at the C1 and C3 benzylic positions with a leaving group, has been demonstrated for the first time as a photoremovable protecting group for time-dependent sequential release of two (same or different) carboxylic acids ...
A. Sikder, Moumita Banerjee, Tara Singha, Saugat Mondal, P. Datta, A. Anoop, N. Singh   +6 more
semanticscholar   +1 more source

Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability.

Bioorganic chemistry (Print), 2020
A series of new β-carboline linked aryl sulfonyl piperazine congeners have been synthesized by coupling various β-carboline acids with substituted aryl sulfonyl piperazines.
Kesari Lakshmi Manasa, Sowjanya Thatikonda, D. K. Sigalapalli, Arpita Sagar, G. Kiranmai, Arunasree M. Kalle, Mallika Alvala, C. Godugu, N. Nagesh, B. Nagendra Babu   +9 more
semanticscholar   +1 more source

β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition.

Journal of Ethnopharmacology, 2019
ETHNOPHARMACOLOGICAL RELEVANCE The plant Arenaria kansuensis is used in traditional medicine to treat lung inflammation for a long time. However, the anti-pulmonary fibrosis effect and its corresponding bioactive constituents of this plant have not been ...
Yulei Cui, Lei Jiang, Ruitao Yu, Y. Shao, L. Mei, Y. Tao   +5 more
semanticscholar   +1 more source

Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates.

Bioorganic & Medicinal Chemistry Letters, 2019
A series of 1H-1,2,3-triazole/acylhydrazide-tethered tetrahydro-β-carboline-4-aminoquinoline conjugates was synthesized with an aim to study their anti-plasmodial structure-activity relationship.
Bharvi Sharma, Simranjeet Kaur, J. Legac, P. Rosenthal, Vipan Kumar   +4 more
semanticscholar   +1 more source

Enantiomeric β-carboline dimers from Picrasma quassioides and their anti-hepatoma potential.

Phytochemistry, 2019
Four pairs of enantiomeric β-carboline alkaloids, (+/-)-kumudine A-D, along with their biosynthesis-related compound kumudine E, were obtained from the stems of Picrasma quassioides.
Wen-Yu Zhao, Wei-Yu Zhou, Jing-Jie Chen, Guo-Dong Yao, B. Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shaojiang Song   +7 more
semanticscholar   +1 more source

New 3-tetrazolyl-β-carbolines and β-carboline-3-carboxylates with anti-cancer activity.

European journal of medicinal chemistry, 2019
The synthesis and in vitro anticancer activity of novel β-carbolines is reported. New tryptamines have been prepared via hetero-Diels-Alder reaction of nitrosoalkenes with indoles and used to prepare functionalized β-carbolines by the Pictet-Spengler ...
M. R. Panice, Susana M. M. Lopes, M. C. Figueiredo, A. L. T. Goes Ruiz, M. Foglio, A. S. Nazari Formagio, M. Sarragiotto, T. M. Pinho e Melo   +7 more
semanticscholar   +1 more source