Results 91 to 100 of about 101,136 (248)

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

Optimization and partial purification of beta-galactosidase production by Aspergillus niger isolated from Brazilian soils using soybean residue

AMB Express, 2019
β-Galactosidases are widely used for industrial applications. These enzymes could be used in reactions of lactose hydrolysis and transgalactosylation. The objective of this study was the production, purification, and characterization of an extracellular ...
Raquel Dall’Agnol Martarello, Luana Cunha, Samuel Leite Cardoso, Marcela Medeiros de Freitas, Damaris Silveira, Yris Maria Fonseca-Bazzo, Mauricio Homem-de-Mello, Edivaldo Ximenes Ferreira Filho, Pérola Oliveira Magalhães   +8 more
doaj   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Creation of a Pseudotsuga menziesii nucellus cell suspension culture system to produce proteins involved in reproduction

Applications in Plant Sciences, EarlyView.
Abstract Premise Cell suspension cultures of Douglas‐fir (Pseudotsuga menziesii) nucellus were created to overcome phenological limitations to the in situ study of bioactive proteins within and secreted by nucellar cells. Methods Proteins isolated from the cell suspension culture medium were analyzed using mass spectrometry, as were Douglas‐fir post ...
Andrea Coulter, YuQi Li, Julia Lakhani, Natalie Prior, Patrick von Aderkas   +4 more
wiley   +1 more source

Simple and Mixed Reverse Micelles as Potential Bioreactors for Enzymatic Synthesis of Alkyl Glycosides – Environmentally Friendly Surfactants

Food Technology and Biotechnology, 2012
Two types of microemulsion reaction systems: simple and mixed reverse micelles have been investigated as potential bioreactors for a transglycosylation reaction catalyzed by three microbial β-galactosidases: fungal Aspergillus oryzae, yeast Kluyveromyces
Irina Mladenoska
doaj  

CreA-mediated carbon catabolite repression of β-galactosidase formation inAspergillus nidulansis growth rate dependent [PDF]

FEMS Microbiology Letters, 2004
Hedvig Ilyés, Erzsébet Fekete, Levente Karaffa, Éva Fekete, Erzsébet Sándor, Attila Szentirmai, Christian P. Kubicek   +6 more
openaire   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia

Molecular Imaging, 2007
Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator.
Ivana Cecic, Denise A. Chan, Patrick D. Sutphin, Pritha Ray, Sanjiv Sam Gambhir, Amato J. Giaccia, Edward E. Graves   +6 more
doaj   +1 more source

Secretion and properties of a hybrid Kluyveromyces lactis-Aspergillus niger β-galactosidase

Microbial Cell Factories, 2006
Background The β-galactosidase from Kluyveromyces lactis is a protein of outstanding biotechnological interest in the food industry and milk whey reutilization.
Becerra Manuel, Siso M Isabel, Cerdán M Esperanza, Trillo M Cristina, Leiro Rafael, Rodríguez Ángel   +5 more
doaj   +1 more source