Results 211 to 220 of about 2,747,637 (331)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Safety evaluation of an extension of use of the food enzyme β-galactosidase from the genetically modified <i>Bacillus licheniformis</i> strain NZYM-BT. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Cavanna D, Liu Y, Tokić V.   +15 more
europepmc   +1 more source

DnaK1‐mediated regulation of phototactic motility in Synechococcus elongatus UTEX 3055

mLife, EarlyView.
Abstract Cyanobacterial phototaxis relies on type IV pili (T4P); yet, how light signals are transmitted to the T4P motor remains unresolved. Here, we identify the molecular chaperone DnaK1 as an important regulator of phototactic motility in Synechococcus elongatus UTEX 3055.
Shang‐Yu Li, Qing‐Xue Sun, Dan‐Qing Huang, Tao Xie, Yan Yu, Chenliu He, Cesar A. Valades‐Cruz, Xiaoli Zeng, Yiling Yang, Cheng‐Cai Zhang   +9 more
wiley   +1 more source

Near-infrared fluorescent probe-mediated high-throughput discovery of a natural β-galactosidase inhibitor for senescence-associated atherosclerosis therapy. [PDF]

J Pharm Anal
Qin Y, Li N, Yang W, Wu Y, Tang Z, Xin J, Jiang H.   +6 more
europepmc   +1 more source

Purification and Some Properties of β-Mannosidase, β-N-Acetylglucosaminidase, and β-Galactosidase from Apple Snails (Pomacea canaliculata)

β -Mannosidase, β -N-acetylglucosaminidase, and β -galactosidase were purified from the viscera of apple snails (Pomacea canaliculata) using ammonium sulfate precipitation, hydrophobic chromatography on Butyl Toyopearl 650M, gel filtration on Sephacryl S-
Aso, Yoichi, Hirata, Koji, 平田, 考治, Ishiguro, Masatsune, 石黒, 正恒, 麻生, 陽一   +5 more
core  

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

Frosted DNA: β-Galactosidase Control of Oligonucleotide Activity. [PDF]

Chemistry
Sinsel F, Külp M, Rieger MA, Heckel A.
europepmc   +1 more source

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF‐κB Suppression and GSK3β/β‐Catenin Activation in Diabetic Osteoporosis

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its direct molecular targets and integrated mechanisms remain unclear.
Wenqi Jin, Yujing Tan, Lei Zhang, Weigeng She, Yunhang Chu, Xuenan Chen, Shuai Zhang, Liwei Sun   +7 more
wiley   +1 more source

Species-selective activation of a β-galactosidase fluorogenic probe. [PDF]

Sci Rep
Jaskot K, Mielcarek A, Popenda Ł, Kertmen A, Grześkowiak BF, Barciszewski J, Perrigue PM.   +6 more
europepmc   +1 more source

4′‐Hydroxywogonin Attenuates Hepatocellular Carcinoma Progression by Suppressing Gas6/Axl‐PI3K/AKT Signaling

Phytotherapy Research, EarlyView.
4′‐Hydroxywogonin, a flavonoid derived from Scutellaria baicalensis, inhibits hepatocellular carcinoma progression partly by suppressing Gas6/Axl‐PI3K/AKT signaling, inducing cell cycle arrest and apoptosis, and reducing metastatic potential. It also suppresses xenograft tumor growth without evident hepatotoxicity.
Chi‐Yuan Chen, Chin‐Chuan Chen, Chau‐Ting Yeh, Chieh‐Wen Chan, Yu‐De Chu, Yann‐Lii Leu, Roshan B. Satange, Li‐Fang Chou, Wen‐Yu Chuang, Chuen Hsueh, Tzong‐Ming Shieh, Tong‐Hong Wang   +11 more
wiley   +1 more source