Results 241 to 250 of about 2,747,637 (331)

The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer

Cancer Science, EarlyView.
SETX maintains R‐loop homeostasis by resolving excessive R‐loops, thereby promoting tumor initiation and chemoresistance. Deficiency of SETX leads to accumulation of unsolved pathological R‐loops, resulting in irreparable DNA damage and ultimately leading to tumor suppression and chemosensitivity.
Zi‐Wei Hu, Tu‐Nan Xu, Zi‐Ying Wang, Xin Zheng, Duan‐Yong Feng, Xiao‐Min Wang, Er‐Suo Jin, Ming Ren, Xiao‐Min Yang, Xian‐Chao Zhang, Xuan Che, Wei‐Wei Pan, Zha‐Jun Zhan, Shu‐Qun Cheng   +13 more
wiley   +1 more source

Optimization of solid-state fermentation conditions for high β-galactosidase-producing lactic acid bacteria and its application in low-lactose dairy products. [PDF]

Front Bioeng Biotechnol
Zhang Z.
europepmc   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

β-Galactosidase-Catalyzed Transglycosylation of Tyrosol: Substrates and Deep Eutectic Solvents Affecting Activity and Stability. [PDF]

Biomolecules
Koššuthová A, Antošová M, Bauerová-Hlinková V, Bauer JA, Polakovič M.   +4 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

A GH42 β‑Galactosidase from the Human Isolate <i>Bifidobacterium breve</i> DSM 20213: Biochemical and Transgalactosylation Properties Reveal the Potential for Galacto-oligosaccharides Synthesis. [PDF]

ACS Omega
Vu-Le KT, Phirom-On K, Sripattanakul S, Chu DB, Hann S, Blaukopf M, Suetzl L, Oostenbrink C, Haltrich D, Nguyen TH.   +9 more
europepmc   +1 more source

New β-galactosidase producers with potential for prebiotic synthesis.

Bioresource Technology, 2018
Sara C. Silvério, E. Macedo, J. Teixeira, L. Rodrigues   +3 more
semanticscholar   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Characterization of a β-Galactosidase from <i>Kosakonia oryzendophytica</i> and Its Heterologous Expression in <i>Bacillus subtilis</i> for Galactooligosaccharides Production. [PDF]

Molecules
Cheng Z, Jin X, Zhang Y, Ni D, Zhu Y, Xu W, Zhang W, Mu W.   +7 more
europepmc   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source