Results 101 to 110 of about 2,651,221 (311)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Development of Fish Immunity and the Role of β-Glucan in Immune Responses

Molecules, 2020
Administration of β-glucans through various routes, including immersion, dietary inclusion, or injection, have been found to stimulate various facets of immune responses, such as resistance to infections and resistance to environmental stress.
Marianna V. Rodrigues, Fábio S. Zanuzzo, João Fernando A. Koch, Carlos Alberto F. de Oliveira, Petr Sima, Vaclav Vetvicka   +5 more
doaj   +1 more source

Production of stable emulsions using β-glucans extracted from Pleurotus ostreatus to encapsulate oxidizable compounds [PDF]

, 2021
The basidiomycete Pleurotus ostreatus is a sustainable food source known to be rich in β-glucans, functional compounds in mushrooms recognized for their numerous health, nutraceutical, and physicochemical properties.
Lavelli, Vera, Francesca Gallotti, Christelle Turchiuli, F. Gallotti, V. Lavelli, Turchiuli, Christelle, Gallotti, Francesca, C. Turchiuli, Vera Lavelli   +8 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Management of Hypercholesterolemia Through Dietary ß-glucans–Insights From a Zebrafish Model

Frontiers in Nutrition, 2022
Consumption of lipid-rich foods can increase the blood cholesterol content. β-glucans have hypocholesterolemic effect. However, subtle changes in their molecular branching can influence bioactivity.
Adnan Hussain Gora, Saima Rehman, Viswanath Kiron, Jorge Dias, Jorge M. O. Fernandes, Pål Asgeir Olsvik, Prabhugouda Siriyappagouder, Ioannis Vatsos, Ulrike Schmid-Staiger, Konstantin Frick, Miguel Cardoso   +10 more
doaj   +1 more source

Expression and β-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

Plant Molecular Biology, 2011
Scots pine (Pinus sylvestris) secretes a number of small, highly-related, disulfide-rich proteins (Sp-AMPs) in response to challenges with fungal pathogens such as Heterobasidion annosum, although their biological role has been unknown. Here, we examined the expression patterns of these genes, as well as the structure and function of the encoded ...
Sooriyaarachchi, Sanjeewani, Jaber, Emad, Covarrubias, Adrian Suárez, Ubhayasekera, Wimal, Asiegbu, Frederick O, Mowbray, Sherry L   +5 more
openaire   +5 more sources

A review on pharmacological insights of edible and medicinal mushroom based β-glucans

Applied Biological Chemistry
Mushrooms are considered as health boosting medicinal fungi for hundred years that contains β -glucans mainly β-D-glucose, a bioactive components presents on the cell wall of fungi. β-glucans are not synthesized de novo but has important role in terms of
Mohammad Moniruzzaman, Do Thi Cat Tuong, Sungyeon Chin, Sureshbabu Anjana, Adhimoolam Karthikeyan, Taesun Min, In-Jung Kim   +6 more
doaj   +1 more source

PHYSICOCHEMICAL COMPARISON OF COMMERCIAL VS. EXTRACTED β-GLUCANS AND STRUCTURAL CHARACTERIZATION AFTER ENZYMATIC PURIFICATION

Vitae
Background: β-glucans (1-3: 1-4) are soluble fibers applied to foods due to their technological properties (water binding capacity, viscosity, emulsification and stabilization) and their beneficial effects on health.
Sandra Milena VASQUEZ- MEJIA, Alicia de FRANCISCO, Pedro Luiz MANIQUE BARRETO, Bruna MATTIONI, André Wüst ZIBETTI, Luciano MOLOGNONI, Heitor DAGUER   +6 more
doaj   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source